MANNOSE-BINDING LECTIN KNOCK-OUT MICE AND METHODS OF USE THEREOF

Title:

MANNOSE-BINDING LECTIN KNOCK-OUT MICE AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO2006073432

Kind Code:

A9

Abstract:

A transgenic non-human animal with alterations in the MBL gene is prepared by introduction of a gene encoding an altered MBL protein into a host non-human animal. Methods for using transgenic mice so generated to screen for agents that effect MBL's cellular modulating activity are also provided.

Inventors:

TAKAHASHI KAZUE (JP)
EZEKOWITZ R ALAN (US)
SHI LEI (CN)

Application Number:

PCT/US2005/013549

Publication Date:

August 24, 2006

Filing Date:

April 20, 2005

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Assignee:

GEN HOSPITAL CORP (US)
TAKAHASHI KAZUE (JP)
EZEKOWITZ R ALAN (US)
SHI LEI (CN)

International Classes:

A01K67/027

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