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Title:
MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2014/165107
Kind Code:
A3
Abstract:
The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I) The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.

Inventors:
DIETRICH, Evelyne (17 Rue D'orly, Laval Quebec, H2M 1B5, 1B5, CA)
POISSON, Carl (1170 De Louvain East Street, Montreal Quebec, H2M 1B5, 1B5, CA)
GALLANT, Michel (18533 Lagrange Pierrefonds, Pierrefonds Quebec, H9K 1R4, 1R4, CA)
LESSARD, Stephanie (190 Lesieur Apt. 204, St-Jean-sur-Richelieu Quebec, J3A 1P3, 1P3, CA)
LIU, Bingcan (204 St. Aubin Street, Montreal Quebec, H4M 2H9, 2H9, CA)
DAS, Sanjoy, Kumar (4451 King Street, Pierrefonds Quebec, H9H 2G2, 2G2, CA)
RAMTOHUL, Yeeman (12665 Boulevard Gouin Ouest, Pierrefonds Quebec, H8Z 1W6, 1W6, CA)
REDDY, Thumkunta, Jagadeeswar (12546 Bedford Street, Pierrefonds Quebec, H9A 3K5, 3K5, CA)
MARTEL, Julien (10129 Lajeunesse Street, #3Montrea, Quebec H2E 2G6, 2G6, CA)
VALLEE, Frederic (7272 Papineau, Montreal Quevec, H2E 2GE, 2GE, CA)
LEVESQUE, Jean-francois (2745 Place Dollard, Laval Quebec, H7E 3T8, 3T8, CA)
Application Number:
US2014/024411
Publication Date:
February 26, 2015
Filing Date:
March 12, 2014
Export Citation:
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Assignee:
VERTEX PHARMACEUTICALS INCORPORATED (50 Northern Avenue, 15th FloorBoston, MA, 02210, US)
International Classes:
C07H15/18; A61K31/7034; C07D493/10; C07H15/20; C07H15/207; C07H15/22; C07H15/26
Domestic Patent References:
WO2011050323A12011-04-28
WO2012164074A12012-12-06
WO2012109263A12012-08-16
WO2011073112A22011-06-23
WO2005089733A22005-09-29
Other References:
ZHENFU HAN ET AL: "Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 53, no. 12, 24 June 2010 (2010-06-24), pages 4779 - 4792, XP002620405, ISSN: 0022-2623, [retrieved on 20100527], DOI: 10.1021/JM100438S
TOBIAS KLEIN ET AL: "FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 53, no. 24, 23 December 2010 (2010-12-23), pages 8627 - 8641, XP002620404, ISSN: 0022-2623, [retrieved on 20101124], DOI: 10.1021/JM101011Y
Attorney, Agent or Firm:
CHE, Jennifer G. (Vertex Pharmaceuticals Incorporated, 50 Northern Avenue 15th Floo, Boston MA, 02210, US)
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