Title:
MARKED FATTY ACID DERIVATIVE, PRECURSOR COMPOUND THEREOF, AND USE THEREOF IN CONTRAST AGENT
Document Type and Number:
WIPO Patent Application WO/2023/246564
Kind Code:
A1
Abstract:
The present invention relates to a marked fatty acid derivative, a precursor compound thereof, and use thereof in a contrast agent. The derivative is represented by formula I: wherein M is 99mTc or Re; R, R1, R2, R3, R4 and R5, and A1-A12 are independently H, an aliphatic chain or an alicyclic; J, X, and Y are independently absent, or -O-, -S- or (II), and J, X, and Y are not simultaneously absent; R6-R14 are independently H or an aliphatic chain, and R13 and R14 are not H simultaneously; z is 1-6, a is 0-5, b is 0-5, and c is 0-3; d is 0-27, e is 0-27, f is 0-28, g is 0-7, and at least two of d, e, f and g are not 0. The present invention provides a completely novel structure type that can be used for preparing a novel myocardial metabolism contrast agent, possessing important clinical application prospects.
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Inventors:
ZHANG HUABEI (CN)
FANG YU (CN)
FANG YU (CN)
Application Number:
PCT/CN2023/099946
Publication Date:
December 28, 2023
Filing Date:
June 13, 2023
Export Citation:
Assignee:
UNIV BEIJING NORMAL (CN)
International Classes:
C07F13/00; A61K49/06
Foreign References:
| CN110698515A | 2020-01-17 | |||
| US4735793A | 1988-04-05 |
Other References:
LIU, S. ; HE, Z. ; HSIEH, W.Y. ; KIM, Y.S.: "Evaluation of novel cationic ^9^9^mTc-nitrido complexes as radiopharmaceuticals for heart imaging: improving liver clearance with crown ether groups", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY., US, vol. 33, no. 3, 1 April 2006 (2006-04-01), US , pages 419 - 432, XP027962871, ISSN: 0969-8051
BOSCHI ALESSANDRA, UCCELLI LICIA, BOLZATI CRISTINA, DUATTI ADRIANO: "Synthesis and biologic evaluation of monocationic asymmetric ^sup 99m^Tc-nitride heterocomplexes showing high heart uptake and improved imaging properties", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 44, no. 5, 1 May 2003 (2003-05-01), US , pages 806 - 814, XP093121250, ISSN: 0161-5505
BOSCHI ALESSANDRA, UCCELLI LICIA, BOLZATI CRISTINA, DUATTI ADRIANO: "Synthesis and biologic evaluation of monocationic asymmetric ^sup 99m^Tc-nitride heterocomplexes showing high heart uptake and improved imaging properties", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 44, no. 5, 1 May 2003 (2003-05-01), US , pages 806 - 814, XP093121250, ISSN: 0161-5505
Attorney, Agent or Firm:
BEIJING ZHI CHENG HAN FANG IP AGENCY CO., LTD. (CN)
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