Title:
MARKER FOR DETECTING HIGHLY PATHOGENIC INFLUENZA VIRUS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/101747
Kind Code:
A2
Abstract:
The present invention relates to a marker for detecting a highly pathogenic influenza virus and a use thereof, and more particularly, to a marker for detecting a highly pathogenic influenza virus, which includes a protein mutant prepared by substituting the amino acids 68 and 69 of a PB1-F2 protein, a composition for detecting a highly pathogenic virus, which includes an agent for measuring the protein mutant, and a detection kit including the same, a method for detecting a highly pathogenic virus, which includes measuring the protein mutant, an antiviral composition against influenza A virus, which includes an inhibitor of binding between a PB1-F2 protein in which the amino acids 68 and 69 are substituted and DDX3, and a method for screening an antiviral substance against influenza A virus. In the present invention, as the correlation between a 1918 PB1-F2 protein and high pathogenicity of the virus and a molecular mechanism thereof were first identified, a protein mutant prepared by substituting the amino acids 68 and 69 in the PB1-F2 protein sequence of an influenza virus can be used as a marker for detecting a highly pathogenic virus, and a highly pathogenic virus may be effectively detected by measuring the mutant. In addition, the viral mechanism of the evasion of innate immunity by the PB1-F2 protein mutant newly identified in the present invention may provide a new understanding for developing an antiviral agent, and the antiviral composition according to the present invention may be effectively used in the development of an antiviral agent.
Inventors:
KIM KYUN-HWAN (KR)
PARK EUN SOOK (KR)
PARK YEONG-MIN (KR)
SEONG BAIK LIN (KR)
BYUN YOUNG HO (KR)
LEE HYE MIN (KR)
PARK EUN SOOK (KR)
PARK YEONG-MIN (KR)
SEONG BAIK LIN (KR)
BYUN YOUNG HO (KR)
LEE HYE MIN (KR)
Application Number:
PCT/KR2017/013843
Publication Date:
June 07, 2018
Filing Date:
November 29, 2017
Export Citation:
Assignee:
KONKUK UNIV GLOCAL INDUSTRYACADEMIC COLLABORATION FOUNDATION (KR)
Other References:
See references of EP 3548893A4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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