Title:
MARKER FOR DETECTION OF MYOGENIC DISEASES, AND METHOD FOR DETECTION OF THE DISEASES USING SAME
Document Type and Number:
WIPO Patent Application WO/2011/105556
Kind Code:
A1
Abstract:
Disclosed is a method for detecting myogenic diseases, which is less invasive, does not undergo the influence of exercises loads, and has high sensitivity.
In the method, the level of at least one component selected from miR-1, miR-133a, miR-133b and miR-206 in blood collected from a subject is measured, and it is determined that the subject is suffering from a myogenic disease when the blood miRNA component level in the subject is statistically significantly higher compared with those in normal individuals.
Inventors:
HASHIDO KAZUO (JP)
MIZUNO HIDEYA (JP)
MIZUNO HIDEYA (JP)
Application Number:
PCT/JP2011/054318
Publication Date:
September 01, 2011
Filing Date:
February 25, 2011
Export Citation:
Assignee:
NAT CT NEUROLOGY & PSYCHIATRY (JP)
HASHIDO KAZUO (JP)
MIZUNO HIDEYA (JP)
HASHIDO KAZUO (JP)
MIZUNO HIDEYA (JP)
International Classes:
C12N15/09; C12N15/113; C12Q1/68
Domestic Patent References:
| WO2009134710A2 | 2009-11-05 |
Foreign References:
| JPH11313682A | 1999-11-16 | |||
| JP2005304481A | 2005-11-04 | |||
| JP2010041845A | 2010-02-18 |
Other References:
MCCARTHY J.J. ET AL: "MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse", AM J PHYSIOL CELL PHYSIOL, vol. 293, 2007, pages C451 - C457
CALLIS T.E. ET AL: "Muscling through the microRNA world", EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 233, no. 2, 2008, pages 131 - 138
EISENBERG I. ET AL: "miRNAs in normal and diseased skeletal muscle", J. CELL. MOL. MED., vol. 13, no. 1, 2009, pages 2 - 11
GRECO S. ET AL: "Common micro-RNA signature in skeletal muscle damage and regeneration induced by duchenne muscular dystrophy and acute ischemia", THE FASEB JOURNAL, vol. 23, October 2009 (2009-10-01), pages 3335 - 3346, XP002594658
ARASHIRO P. ET AL: "Transcriptional regulation differs in affected facioscapulohumeral muscular dystrophy patients compared to asymptomatic related carriers", PNAS, vol. 106, no. 15, April 2009 (2009-04-01), pages 6220 - 6225
EISENBERG I. ET AL: "Distinctive patterns of microRNA expression in primary muscular disorders", PNAS, vol. 104, no. 43, October 2007 (2007-10-01), pages 17016 - 17021
"Principle of Myology", 1995, NANKODO CO., LTD., pages: 469 - 550
SUGITA H. ET AL., J. BIOCHEM., vol. 46, 1959, pages 103 - 104
KIM ET AL., J. CELL BIOCHEM, vol. 174, 2006, pages 677 - 687
BARTEL DP, CELL, vol. 116, 2004, pages 281 - 297
KIM ET AL., J. CELL BIOCHEM., vol. 174, 2006, pages 677 - 687
SAMBROOK, J.: "Molecular Cloning: a Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
NISHINO AND SANO: "Current Protocols in Molecular Biology", vol. I, 1997, MARUZEN CO., LTD
"DNA Microarray and Latest PCR Method", 2000, GAKKEN MEDICAL SHUJUNSHA CO., LTD.
KAZUHIRO NAGATA; HIROSHI HANDA: "Real-Time Analysis of Biomolecular Interactions", 2000, SPRINGER-VERLAG TOKYO, INC.
J. CHRISTOPHER LOVE; L.A. ESTROFF; J.K. KRIEBEL; R.G. NUZZO, G.M.: "Whitesides (2005) Self-Assembled Monolayers of a Form of Nanotechnology", CHEMICAL REVIEW, vol. 105, 2005, pages 1103 - 1169
"Toyosaka Moriizumi and Takamichi Nakamoto", 1997, SENSOR ENGINEERING, SHOKODO CO., LTD
"Molecular Cloning: a Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2540829A4
CALLIS T.E. ET AL: "Muscling through the microRNA world", EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 233, no. 2, 2008, pages 131 - 138
EISENBERG I. ET AL: "miRNAs in normal and diseased skeletal muscle", J. CELL. MOL. MED., vol. 13, no. 1, 2009, pages 2 - 11
GRECO S. ET AL: "Common micro-RNA signature in skeletal muscle damage and regeneration induced by duchenne muscular dystrophy and acute ischemia", THE FASEB JOURNAL, vol. 23, October 2009 (2009-10-01), pages 3335 - 3346, XP002594658
ARASHIRO P. ET AL: "Transcriptional regulation differs in affected facioscapulohumeral muscular dystrophy patients compared to asymptomatic related carriers", PNAS, vol. 106, no. 15, April 2009 (2009-04-01), pages 6220 - 6225
EISENBERG I. ET AL: "Distinctive patterns of microRNA expression in primary muscular disorders", PNAS, vol. 104, no. 43, October 2007 (2007-10-01), pages 17016 - 17021
"Principle of Myology", 1995, NANKODO CO., LTD., pages: 469 - 550
SUGITA H. ET AL., J. BIOCHEM., vol. 46, 1959, pages 103 - 104
KIM ET AL., J. CELL BIOCHEM, vol. 174, 2006, pages 677 - 687
BARTEL DP, CELL, vol. 116, 2004, pages 281 - 297
KIM ET AL., J. CELL BIOCHEM., vol. 174, 2006, pages 677 - 687
SAMBROOK, J.: "Molecular Cloning: a Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
NISHINO AND SANO: "Current Protocols in Molecular Biology", vol. I, 1997, MARUZEN CO., LTD
"DNA Microarray and Latest PCR Method", 2000, GAKKEN MEDICAL SHUJUNSHA CO., LTD.
KAZUHIRO NAGATA; HIROSHI HANDA: "Real-Time Analysis of Biomolecular Interactions", 2000, SPRINGER-VERLAG TOKYO, INC.
J. CHRISTOPHER LOVE; L.A. ESTROFF; J.K. KRIEBEL; R.G. NUZZO, G.M.: "Whitesides (2005) Self-Assembled Monolayers of a Form of Nanotechnology", CHEMICAL REVIEW, vol. 105, 2005, pages 1103 - 1169
"Toyosaka Moriizumi and Takamichi Nakamoto", 1997, SENSOR ENGINEERING, SHOKODO CO., LTD
"Molecular Cloning: a Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2540829A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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