Title:
MARKER FOR DETERMINING MENTAL ILLNESS USING MIRNA
Document Type and Number:
WIPO Patent Application WO/2016/117582
Kind Code:
A1
Abstract:
Developed and provided is a marker for determining mental illness with which it is possible to easily and accurately determine the presence of schizophrenia, depression, or bipolar disorder in a subject. Provided is a marker for determining mental illness from groups comprising miRNA that contains a base sequence shown by SEQ ID NOS: 1-193, the miRNA being contained in cerebrospinal fluid.
Inventors:
HATTORI KOTARO (JP)
KUNUGI HIROSHI (JP)
GOTO YU-ICHI (JP)
KOHSAKA SHINICHI (JP)
KUNUGI HIROSHI (JP)
GOTO YU-ICHI (JP)
KOHSAKA SHINICHI (JP)
Application Number:
PCT/JP2016/051504
Publication Date:
July 28, 2016
Filing Date:
January 20, 2016
Export Citation:
Assignee:
NAT CT NEUROLOGY & PSYCHIATRY (JP)
International Classes:
C12N15/09; C12Q1/68; G01N33/50
Other References:
DATABASE Genbank [o] 2014, "Homo sapiens microRNA 6510 (MIR6510), microRNA", Database accession no. 106765
HANSEN THOMAS ET AL.: "Brain Expressed microRNAs Implicated in Schizophrenia Etiology", PLOS ONE, 2007
"Nanbyo. Gan To no Shikkan Bun'ya no Iryo no Jitsuyoka Kenkyu Jigyo Utsubyo no Byotai o Han'ei suru Kecchu Biomarker no Kaihatsu . Jitsuyoka Kenkyu", KOSEI RODO KAGAKU KENKYUHI HOJOKIN, 19 January 2015 (2015-01-19), pages 3 - 14
GUO AN-YUAN ET AL.: "A Novel microRNA and transcription factor mediated regulatory network in schizophrenia", BMC SYSTEMS BIOLOGY, vol. 4, 2010
SUN XIAOHAN ET AL.: "Identification of putative pathogenic SNPs implied in schizophrenia- associated miRNAs", BMC BIOINFORMATICS, vol. 15, 2014
GRIFFITHS-JONES SAM ET AL.: "miRBase: microRNA sequences, targets and gene nomenclature", NUCLEIC ACIDS RESEARCH, vol. 34, 2006
HANSEN THOMAS ET AL.: "Brain Expressed microRNAs Implicated in Schizophrenia Etiology", PLOS ONE, 2007
"Nanbyo. Gan To no Shikkan Bun'ya no Iryo no Jitsuyoka Kenkyu Jigyo Utsubyo no Byotai o Han'ei suru Kecchu Biomarker no Kaihatsu . Jitsuyoka Kenkyu", KOSEI RODO KAGAKU KENKYUHI HOJOKIN, 19 January 2015 (2015-01-19), pages 3 - 14
GUO AN-YUAN ET AL.: "A Novel microRNA and transcription factor mediated regulatory network in schizophrenia", BMC SYSTEMS BIOLOGY, vol. 4, 2010
SUN XIAOHAN ET AL.: "Identification of putative pathogenic SNPs implied in schizophrenia- associated miRNAs", BMC BIOINFORMATICS, vol. 15, 2014
GRIFFITHS-JONES SAM ET AL.: "miRBase: microRNA sequences, targets and gene nomenclature", NUCLEIC ACIDS RESEARCH, vol. 34, 2006
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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