Title:
MARKER FOR DIAGNOSING CELLULAR SENESCENCE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/204025
Kind Code:
A1
Abstract:
The present invention relates to a marker for diagnosing cellular senescence and uses thereof. A PAPSS2 gene is capable of performing the role of the marker for diagnosing cellular senescence and thus can be used in a method for diagnosing aging cells, a method for screening a composition for inducing cellular senescence, and a method for screening a composition for suppressing cellular senescence, among others. Also, senescence of non-tumor cells can be induced when the PAPSS2 gene is suppressed in the non-tumor cells.
Inventors:
LEE JAE-SUN (KR)
JUNG SEUNG HEE (KR)
JUNG SEUNG HEE (KR)
Application Number:
PCT/KR2013/005359
Publication Date:
December 24, 2014
Filing Date:
June 18, 2013
Export Citation:
Assignee:
KOREA INST RADL & MED SCIENCES (KR)
International Classes:
C12Q1/68; C12N15/11; G01N33/563; G01N33/68
Domestic Patent References:
| WO2010065567A2 | 2010-06-10 | |||
| WO2000046391A2 | 2000-08-10 |
Foreign References:
| US20030195162A1 | 2003-10-16 |
Other References:
ZHANG ET AL.: "Energy restriction does not compensate for the reduced expression of hepatic drug-processing genes in mice with aging", D RUG METABOLISM AND DISPOSITION, vol. 38, no. 7, 31 July 2010 (2010-07-31), pages 1122 - 1131
BAPAT ET AL.: "Gene expression: protein interaction systems network modeling identifies transformation-associated molecules and pathways in ovarian cancer", CANCER RESEARCH, vol. 70, no. 12, 8 June 2010 (2010-06-08), pages 4809 - 4819
BAPAT ET AL.: "Gene expression: protein interaction systems network modeling identifies transformation-associated molecules and pathways in ovarian cancer", CANCER RESEARCH, vol. 70, no. 12, 8 June 2010 (2010-06-08), pages 4809 - 4819
Attorney, Agent or Firm:
AHN, So-Young (KR)
안소영 (KR)
안소영 (KR)
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