Title:
MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE
Document Type and Number:
WIPO Patent Application WO/2015/087985
Kind Code:
A1
Abstract:
The present invention addresses the problem of identifying a biomarker of kidney failure, said biomarker being available from urine or blood and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a kidney failure suspected subject comprises a step for, with respect to at least one kind of amino acid pair selected from the group consisting of [D-serine] and [L-serine], etc. contained in the blood, plasma, serum or urine of the subject, calculating, as an index of pathology of the subject, the ratio of the D-isomer concentration to the L-isomer concentration or the percentage of the D-isomer concentration relative to the total concentration of the D- and L-isomers.
Inventors:
HAMASE KENJI (JP)
MIYOSHI YURIKA (JP)
MITA MASASHI (JP)
MIYOSHI YURIKA (JP)
MITA MASASHI (JP)
Application Number:
PCT/JP2014/082899
Publication Date:
June 18, 2015
Filing Date:
December 11, 2014
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
G01N33/68; G01N33/493
Domestic Patent References:
| WO2013140785A1 | 2013-09-26 |
Foreign References:
| JP4291628B2 | 2009-07-08 | |||
| JP2008027650A | 2008-02-07 |
Other References:
MAGDALENA C. ET AL.: "Comparison of derivatization and chromatographic methods for GC.MS analysis of amino acid enantiomers in physiological samples", JOURNAL OF CHROMATOGRAPHY B, vol. 878, 2010, pages 1103 - 1112, XP027015420
TAKESHI FUKUSHIMA ET AL.: "Determination of D- Amino Acids in Serum from Patient with Renal Dysfunction", BIOL. RHARM. BULL., vol. 18, no. 8, 1995, pages 1130 - 1132, XP008073859
YURIKA MIYOSHI ET AL.: "Development of a Simultaneous Two-dimensional Micro-HPLC Analysis System for the Chiral Amino Acid Metabolomics Study in Mammals", JOURNAL OF JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY, vol. 61, no. 6, 2012, pages 489 - 499, XP055348840
KENJI HAMASE ET AL.: "Kogaku Iseitai o Kubetsu suru Zen Amino Acid Nijigen HPLC Issei Bunsekiho no Kaihatsu to Soyaku·Shindan eno Tenkai", BIOMEDICAL BUNSEKI KAGAKU SYMPOSIUM KOEN YOSHISHU, vol. 23 RD, 21 July 2010 (2010-07-21), pages 16 - 17, XP008183951
JUMPEI SASABE ET AL.: "Ischemic Acute Kidney Injury Perturbs Homeostasis of Serine Enantiomers in the Body Fluid in Mice: Early Detection of Renal Dysfunction Using the Ratio of Serine Enantiomers", PLOS ONE, vol. 9, no. ISSUEL, January 2014 (2014-01-01), pages E86504, XP055348838
See also references of EP 3081939A4
KDIGO: "Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease", KIDNEY INTERNATIONAL SUPPLEMENTS, vol. 1, 2012
SLOCUM, J. L. ET AL., TRANSL. RES., vol. 159, 2012, pages 277
FUKUSHIMA, T. ET AL., BIOL. PHARM. BULL., vol. 18, 1995, pages 1130
ZHANG, H. ET AL., AMINO ACIDS, vol. 42, 2012, pages 337
ISHIDA ET AL., KITASATO MEDICAL JOURNAL, vol. 23, 1993, pages 51 - 62
YONG HUANG ET AL., BIOL. PHARM. BULL., vol. 21, no. 2, 1998, pages 156 - 162
MAGDALENA C. WALDHIER ET AL., CHROMATOGRAPHY B, 2010, pages 1103 - 1112
JUMPEJI SASABE ET AL., PLOS ONE, vol. 9, no. 1, pages E86504
NAGATA, Y.: "Viva Origino", 15TH ACADEMIC SYMPOSIUM, COLLECTION OF ABSTRACTS, vol. 18, no. 2, 1990
HAMASE, K.; ZAITSU, K., ANALYTICAL CHEMISTRY, vol. 53, 2004, pages 677 - 690
JAPANESE SOCIETY OF NEPHROLOGY, 2009
SASABE, J. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 109, 2012, pages 627
MIYOSHI, Y. ET AL., AMINO ACIDS, vol. 43, 2012, pages 1919
MIYOSHI, Y. ET AL., J. CHROMATOGR. B, vol. 879, 2011, pages 3194
TAKESHI FUKUSHIMA ET AL.: "Determination of D- Amino Acids in Serum from Patient with Renal Dysfunction", BIOL. RHARM. BULL., vol. 18, no. 8, 1995, pages 1130 - 1132, XP008073859
YURIKA MIYOSHI ET AL.: "Development of a Simultaneous Two-dimensional Micro-HPLC Analysis System for the Chiral Amino Acid Metabolomics Study in Mammals", JOURNAL OF JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY, vol. 61, no. 6, 2012, pages 489 - 499, XP055348840
KENJI HAMASE ET AL.: "Kogaku Iseitai o Kubetsu suru Zen Amino Acid Nijigen HPLC Issei Bunsekiho no Kaihatsu to Soyaku·Shindan eno Tenkai", BIOMEDICAL BUNSEKI KAGAKU SYMPOSIUM KOEN YOSHISHU, vol. 23 RD, 21 July 2010 (2010-07-21), pages 16 - 17, XP008183951
JUMPEI SASABE ET AL.: "Ischemic Acute Kidney Injury Perturbs Homeostasis of Serine Enantiomers in the Body Fluid in Mice: Early Detection of Renal Dysfunction Using the Ratio of Serine Enantiomers", PLOS ONE, vol. 9, no. ISSUEL, January 2014 (2014-01-01), pages E86504, XP055348838
See also references of EP 3081939A4
KDIGO: "Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease", KIDNEY INTERNATIONAL SUPPLEMENTS, vol. 1, 2012
SLOCUM, J. L. ET AL., TRANSL. RES., vol. 159, 2012, pages 277
FUKUSHIMA, T. ET AL., BIOL. PHARM. BULL., vol. 18, 1995, pages 1130
ZHANG, H. ET AL., AMINO ACIDS, vol. 42, 2012, pages 337
ISHIDA ET AL., KITASATO MEDICAL JOURNAL, vol. 23, 1993, pages 51 - 62
YONG HUANG ET AL., BIOL. PHARM. BULL., vol. 21, no. 2, 1998, pages 156 - 162
MAGDALENA C. WALDHIER ET AL., CHROMATOGRAPHY B, 2010, pages 1103 - 1112
JUMPEJI SASABE ET AL., PLOS ONE, vol. 9, no. 1, pages E86504
NAGATA, Y.: "Viva Origino", 15TH ACADEMIC SYMPOSIUM, COLLECTION OF ABSTRACTS, vol. 18, no. 2, 1990
HAMASE, K.; ZAITSU, K., ANALYTICAL CHEMISTRY, vol. 53, 2004, pages 677 - 690
JAPANESE SOCIETY OF NEPHROLOGY, 2009
SASABE, J. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 109, 2012, pages 627
MIYOSHI, Y. ET AL., AMINO ACIDS, vol. 43, 2012, pages 1919
MIYOSHI, Y. ET AL., J. CHROMATOGR. B, vol. 879, 2011, pages 3194
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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