Title:
MARKER GENE FOR MALIGNANT BRAIN TUMOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/034603
Kind Code:
A1
Abstract:
Disclosed are a marker gene which can serve as an indicator of malignant brain tumor and use of the marker gene. A brain tumor marker gene having any one of the nucleotide sequences depicted in SEQ ID NOs:1-17; a brain tumor marker protein having a polypeptide comprising the amino acid sequence depicted in any one of SEQ ID NOs:18-34; a method for the diagnosis of malignant brain tumor using the expression of the marker gene or marker protein as an indiator; a method for the screening of a substance capable of inhibiting the expression of the marker gene or marker protein; and a kit for the diagnosis of malignant brain tumor utilizing the marker gene or marker protein.
Inventors:
YAMANAKA RYUYA (JP)
NISHIO KAZUTO (JP)
SEKIJIMA MASARU (JP)
NISHIO KAZUTO (JP)
SEKIJIMA MASARU (JP)
Application Number:
PCT/JP2006/312267
Publication Date:
March 29, 2007
Filing Date:
June 20, 2006
Export Citation:
Assignee:
UNIV NIIGATA (JP)
YAMANAKA RYUYA (JP)
NISHIO KAZUTO (JP)
SEKIJIMA MASARU (JP)
YAMANAKA RYUYA (JP)
NISHIO KAZUTO (JP)
SEKIJIMA MASARU (JP)
International Classes:
C12N15/09; C07K14/82; C07K16/32; C12M1/00; C12Q1/02; C12Q1/68
Other References:
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DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010194, accession no. NCBI Database accession no. (NM_004219)
DATABASE GENBANK [online] 23 April 2005 (2005-04-23), XP003010195, accession no. NCBI Database accession no. (NM_005825)
DATABASE GENBANK [online] 20 August 2004 (2004-08-20), XP003010196, accession no. NCBI Database accession no. (NM_038150)
DATABASE GENBANK [online] 23 April 2005 (2005-04-23), XP003010197, accession no. NCBI Database accession no. (NM_014840)
DATABASE GENBANK [online] 3 March 2005 (2005-03-03), XP003010198, accession no. NCBI Database accession no. (NM_004445)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010199, accession no. NCBI Database accession no. (NM_004438)
DATABASE GENBANK [online] 2 August 2004 (2004-08-02), XP003010200, accession no. NCBI Database accession no. (NM_004439)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010801, accession no. NCBI Database accession no. (NM_006612)
DATABASE GENBANK [online] 23 April 2005 (2005-04-23), XP003010802, accession no. NCBI Database accession no. (NM_005552)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010803, accession no. NCBI Database accession no. (NM_002254)
DATABASE GENBANK [online] 19 August 2004 (2004-08-19), XP003010804, accession no. NCBI Database accession no. (XM_371332)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010805, accession no. NCBI Database accession no. (NM_006647)
DATABASE GENBANK [online] 22 April 2005 (2005-04-22), XP003010806, accession no. NCBI Database accession no. (NM_004890)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010807, accession no. NCBI Database accession no. (NM_004595)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010808, accession no. NCBI Database accession no. (NM_020404)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010809, accession no. NCBI Database accession no. (NM_005570)
RICH J.N. ET AL.: "Gene expression profiling and genetic markers in glioblastoma survival", CANCER RES., vol. 65, no. 10, May 2005 (2005-05-01), pages 4051 - 4058, XP003010810
FREIJE W.A. ET AL.: "Gene expression profiling of gliomas strongly predicts survival", CANCER RES., vol. 64, no. 18, 2004, pages 6503 - 6510, XP003010811
NUTT C.L. ET AL.: "Gene expression-based classification of malignant gliomas correlates better with survival than histological classification", CANCER RES., vol. 63, no. 7, 2003, pages 1602 - 1607, XP002333921
MISCHEL P.S. ET AL.: "DNA-microarray analysis of brain cancer: molecular classification for therapy", NAT. REV. NEUROSCI., vol. 5, no. 10, 2004, pages 782 - 792, XP003010812
YAMANAKA R. ET AL.: "selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles", INT. J. ONCOL., vol. 23, no. 4, 2003, pages 913 - 923, XP008067948
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010194, accession no. NCBI Database accession no. (NM_004219)
DATABASE GENBANK [online] 23 April 2005 (2005-04-23), XP003010195, accession no. NCBI Database accession no. (NM_005825)
DATABASE GENBANK [online] 20 August 2004 (2004-08-20), XP003010196, accession no. NCBI Database accession no. (NM_038150)
DATABASE GENBANK [online] 23 April 2005 (2005-04-23), XP003010197, accession no. NCBI Database accession no. (NM_014840)
DATABASE GENBANK [online] 3 March 2005 (2005-03-03), XP003010198, accession no. NCBI Database accession no. (NM_004445)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010199, accession no. NCBI Database accession no. (NM_004438)
DATABASE GENBANK [online] 2 August 2004 (2004-08-02), XP003010200, accession no. NCBI Database accession no. (NM_004439)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010801, accession no. NCBI Database accession no. (NM_006612)
DATABASE GENBANK [online] 23 April 2005 (2005-04-23), XP003010802, accession no. NCBI Database accession no. (NM_005552)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010803, accession no. NCBI Database accession no. (NM_002254)
DATABASE GENBANK [online] 19 August 2004 (2004-08-19), XP003010804, accession no. NCBI Database accession no. (XM_371332)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010805, accession no. NCBI Database accession no. (NM_006647)
DATABASE GENBANK [online] 22 April 2005 (2005-04-22), XP003010806, accession no. NCBI Database accession no. (NM_004890)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010807, accession no. NCBI Database accession no. (NM_004595)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010808, accession no. NCBI Database accession no. (NM_020404)
DATABASE GENBANK [online] 2 March 2005 (2005-03-02), XP003010809, accession no. NCBI Database accession no. (NM_005570)
RICH J.N. ET AL.: "Gene expression profiling and genetic markers in glioblastoma survival", CANCER RES., vol. 65, no. 10, May 2005 (2005-05-01), pages 4051 - 4058, XP003010810
FREIJE W.A. ET AL.: "Gene expression profiling of gliomas strongly predicts survival", CANCER RES., vol. 64, no. 18, 2004, pages 6503 - 6510, XP003010811
NUTT C.L. ET AL.: "Gene expression-based classification of malignant gliomas correlates better with survival than histological classification", CANCER RES., vol. 63, no. 7, 2003, pages 1602 - 1607, XP002333921
MISCHEL P.S. ET AL.: "DNA-microarray analysis of brain cancer: molecular classification for therapy", NAT. REV. NEUROSCI., vol. 5, no. 10, 2004, pages 782 - 792, XP003010812
YAMANAKA R. ET AL.: "selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles", INT. J. ONCOL., vol. 23, no. 4, 2003, pages 913 - 923, XP008067948
Attorney, Agent or Firm:
USHIKI, Mamoru (Yusei Fukushi Kotohira Bldg. 14-1, Toranomon 1-chome, Minato-k, Tokyo 01, JP)
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