Title:
MARKER FOR MLH1 METHYLATION GROUP DETERMINATION AND DETERMINATION METHOD
Document Type and Number:
WIPO Patent Application WO/2019/156054
Kind Code:
A1
Abstract:
In one embodiment, the present invention provides a new marker, method, kit, etc., with which it is possible to determine an MLH1 methylation group at high accuracy. In one embodiment, the present invention relates to a marker for mutL homolog 1 (MLH1) methylation group determination, wherein the marker comprises any of (i)-(iii): (i) a nucleic acid molecule including a base sequence shown by SEQ ID NO: 1, (ii) a nucleic acid molecule including a base sequence in which one or several bases have been added, deleted, and/or substituted in SEQ ID NO: 1, and (iii) a fragment of a nucleic acid molecule of (i) or (ii) including one or more CpG sequences.
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Inventors:
KAWAZU MASAHITO (JP)
YAMAMOTO YOKO (JP)
MANO HIROYUKI (JP)
SATO KAZUHITO (JP)
UENO TOSHIHIDE (JP)
IINUMA HISAE (JP)
YAMAMOTO YOKO (JP)
MANO HIROYUKI (JP)
SATO KAZUHITO (JP)
UENO TOSHIHIDE (JP)
IINUMA HISAE (JP)
Application Number:
PCT/JP2019/003992
Publication Date:
August 15, 2019
Filing Date:
February 05, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV TEIKYO (JP)
UNIV TEIKYO (JP)
International Classes:
C12N15/12; C12N15/117; C12Q1/683; G01N33/53; G01N33/574; C07K16/18; C12Q1/42
Domestic Patent References:
| WO2017061609A1 | 2017-04-13 |
Other References:
JENSEN, LH. ET AL.: "Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study", CELLULAR ONCOLOGY, vol. 36, no. 5, 2013, pages 411 - 419, XP055629602, ISSN: 2211-3436, DOI: 10.1007/s13402-013-0148-2
YAOI, TAKESHI: "Methods to Study Epigenetic Mechanisms", JOURNAL OF KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, vol. 118, no. 8, 2009, pages 533 - 541, ISSN: 0023-6012
YAOI, TAKESHI: "Methods to Study Epigenetic Mechanisms", JOURNAL OF KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, vol. 118, no. 8, 2009, pages 533 - 541, ISSN: 0023-6012
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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