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Patent Searching and Data


Title:
MARKER FOR MULTIPLE SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2019/163838
Kind Code:
A1
Abstract:
The present invention provides a method for testing for multiple sclerosis, the method comprising a step for measuring secretory receptor-type protein tyrosine phosphatase Z (PTPRZ) in a sample obtained from a subject. When the measurement value of the secretory PTPRZ level in the sample obtained from the subject is lower in comparison with the PTPRZ levels in samples of a control group, it is indicated that the subject is affected with multiple sclerosis. Said secretory PTPRZ is either secretory PTPRZ isoform 1 or secretory PTPRZ isoform 2, or both.

Inventors:
KITAZUME SHINOBU (JP)
SAKUDA KANOKO (JP)
TANIGUCHI NAOYUKI (JP)
HASHIMOTO YASUHIRO (JP)
HONDA TAKASHI (JP)
SAITO KIYOSHI (JP)
FUJII MASAZUMI (JP)
Application Number:
JP2019/006365
Publication Date:
August 29, 2019
Filing Date:
February 20, 2019
Export Citation:
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Assignee:
RIKEN (JP)
FUKUSHIMA MEDICAL UNIV (JP)
International Classes:
G01N33/68; C12Q1/42; G01N33/53
Foreign References:
JP2017122074A2017-07-13
JP2011178697A2011-09-15
Other References:
SAKUDA, K.: "Reactivity of anti-HNK-1 antibodies to branched 0-mannose glycans associated with demyelination", BIOCHEM BIOPHYS RES COMMUN., vol. 487, no. 2, 27 May 2017 (2017-05-27), pages 450 - 456, XP085014034, DOI: 10.1016/j.bbrc.2017.04.085
SAKUDA, KANOKO ET AL: "Analysis of astrocytes with brain specific branched O-mannosyl glycans in demyelination", THE ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, 2017
AKIHIRO FUJIKAWA ET AL: "Receptor protein tyrosine phosphatase as a drug discovery target: its physiological role and signaling mechanism", SEIKAGAKU, vol. 87, no. 5, 2015, pages 539 - 546
AKIHIRO FUJIKAWA ET AL: "A variety of life phenomena relating to receptor-type tyrosine phosphatase zeta (Ptprz)", SEIKAGAKU, vol. 77, no. 10, 2005, pages 1255 - 1268
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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