Title:
MARKER FOR PREDICTING METASTASIS OF BREAST CANCER
Document Type and Number:
WIPO Patent Application WO/2015/036643
Kind Code:
A3
Abstract:
The invention relates to an in vitro method for predicting metastasis in a subject diagnosed with breast cancer and treated with a taxane, with an in vitro method for the selection of patients with breast cancer that are at risk of developing metastasis following treatment with taxane, and an in vitro method for the design of a personalised therapy for a subject suffering from breast cancer and who is being treated with taxane, based on determining the level of GRP94 and/or FN14. The invention also relates to a composition comprising a taxane and a GRP94 inhibitor and/or an FN14 inhibitor, and to the use thereof in the treatment of cerebral metastasis.
Inventors:
SIERRA JIMÉNEZ ANGELS (ES)
Application Number:
PCT/ES2014/070699
Publication Date:
June 04, 2015
Filing Date:
September 12, 2014
Export Citation:
Assignee:
SIERRA JIMÉNEZ ANGELS (ES)
International Classes:
A61P35/04; G01N33/574
Domestic Patent References:
| WO2010142651A2 | 2010-12-16 | |||
| WO2005000314A1 | 2005-01-06 | |||
| WO2005046593A2 | 2005-05-26 |
Other References:
TOSONI A ET AL: "Chemotherapy in breast cancer patients with brain metastases: Have new chemotherapic agents changed the clinical outcome?", CRITICAL REVIEWS IN ONCOLOGY / HEMATOLOGY, ELSEVIER SCIENCE IRELAND LTD., LIMERICK, IE, vol. 68, no. 3, 1 December 2008 (2008-12-01), pages 212 - 221, XP025780311, ISSN: 1040-8428, [retrieved on 20080612], DOI: 10.1016/J.CRITREVONC.2008.04.004
Attorney, Agent or Firm:
ARIAS SANZ, Juan (S.L.Avda. de Burgos, 16, Edificio Euromor Madrid, ES)
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