Title:
MARKER FOR PREDICTING PROGNOSIS OF PANCREATIC TUMOR
Document Type and Number:
WIPO Patent Application WO/2020/105626
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a biomarker which enables prediction of the prognosis of a patient with a tumor on the basis of the nature of tumor cells themselves. In the present invention, the prognosis of a pancreatic tumor of a subject is predicted by a method for detecting a marker for predicting the prognosis of a pancreatic tumor, the method comprising the step of detecting adipophilin in pancreatic tumor cells collected from the subject.
Inventors:
ISHIDA MITSUAKI (JP)
HASHIMOTO YUKI (JP)
RYOTA HIRONORI (JP)
SATOI SOHEI (JP)
YAMAMOTO TOMOHISA (JP)
YAMAKI SO (JP)
HASHIMOTO YUKI (JP)
RYOTA HIRONORI (JP)
SATOI SOHEI (JP)
YAMAMOTO TOMOHISA (JP)
YAMAKI SO (JP)
Application Number:
PCT/JP2019/045244
Publication Date:
May 28, 2020
Filing Date:
November 19, 2019
Export Citation:
Assignee:
KANSAI MEDICAL UNIV EDUCATIONAL CORPORATION (JP)
International Classes:
C12Q1/68; G01N33/48; G01N33/574
Foreign References:
| US20120115747A1 | 2012-05-10 |
Other References:
TOLKACH, Y ET AL.: "Adipophilin as prognostic biomarker in clear cell renal cell carcinoma", ONCOTARGET, vol. 8, no. 17, 2017, pages 28672 - 28682, XP055710755
STRAUB, B. K. ET AL.: "Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis", MODERN PATHOLOGY, vol. 23, 2010, pages 480 - 492, XP055710756
ONO, M. ET AL.: "Biomarker Discovery of Pancreatic and Gastrointestinal Cancer by 2DICAL: 2- Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry", INTERNATIONAL JOURNAL OF PROTEOMICS, vol. 2012, 10 July 2012 (2012-07-10), XP055710758, Retrieved from the Internet [retrieved on 20200124]
HASHIMOTO, Y. ET AL.: "Adipophilin expression is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma: An immunohistochemical analysis", PANCREATOLOGY, vol. 19, no. 3, 11 March 2019 (2019-03-11), pages 443 - 448, XP055710760
ISHIDA, MITSUAKI ET AL.: "Adipophilin expression is an adverse prognostic factor in pancreatic cancer", TRANSACTIONES SOCIETATIS PATHOLOGICAE JAPONICAE, vol. 108, no. 1, 15 April 2019 (2019-04-15), pages 302
ISHIDA, MITSUAKI ET AL.: "Adipophilin expression in pancreatic cancer cells is an independent adverse prognostic factor", THE OFFICIAL JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE, vol. 67, 20 October 2019 (2019-10-20), pages 197
STRAUB, B. K. ET AL.: "Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis", MODERN PATHOLOGY, vol. 23, 2010, pages 480 - 492, XP055710756
ONO, M. ET AL.: "Biomarker Discovery of Pancreatic and Gastrointestinal Cancer by 2DICAL: 2- Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry", INTERNATIONAL JOURNAL OF PROTEOMICS, vol. 2012, 10 July 2012 (2012-07-10), XP055710758, Retrieved from the Internet
HASHIMOTO, Y. ET AL.: "Adipophilin expression is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma: An immunohistochemical analysis", PANCREATOLOGY, vol. 19, no. 3, 11 March 2019 (2019-03-11), pages 443 - 448, XP055710760
ISHIDA, MITSUAKI ET AL.: "Adipophilin expression is an adverse prognostic factor in pancreatic cancer", TRANSACTIONES SOCIETATIS PATHOLOGICAE JAPONICAE, vol. 108, no. 1, 15 April 2019 (2019-04-15), pages 302
ISHIDA, MITSUAKI ET AL.: "Adipophilin expression in pancreatic cancer cells is an independent adverse prognostic factor", THE OFFICIAL JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE, vol. 67, 20 October 2019 (2019-10-20), pages 197
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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