Title:
MARKER FOR PREDICTING TUMOR REACTIVITY OF LYMPHOCYTES, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/184911
Kind Code:
A1
Abstract:
The present invention relates to a marker for predicting tumor reactivity of lymphocytes, a composition for predicting tumor reactivity, and a method for predicting tumor reactivity. According to the present invention, a predictive model capable of predicting tumor reactivity of cultured lymphocytes can be constructed using a genetic marker, and through the predictive model, the reactivity of lymphocytes is predicted so as to more accurately select lymphocytes specific to a tumor and produce an effective immunotherapeutic agent. In addition, the use of the genetic marker enables lymphocytes to be separated more easily from tissues, blood, or body fluids in a body using non-invasive methods different from conventional invasive methods, and enables only lymphocytes with tumor-specific activity to be selected and used for immunotherapy. Therefore, the present invention is expected to have a wide range of applications.
Inventors:
LEE HEE JIN (KR)
GONG GYUNGYUB (KR)
LEE HEE JAE (KR)
SEO JEONG HAN (KR)
LIM GYEONGBACK (KR)
GONG GYUNGYUB (KR)
LEE HEE JAE (KR)
SEO JEONG HAN (KR)
LIM GYEONGBACK (KR)
Application Number:
PCT/KR2020/003157
Publication Date:
September 17, 2020
Filing Date:
March 06, 2020
Export Citation:
Assignee:
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
C12Q1/6881; G01N33/569
Domestic Patent References:
| WO2018032088A2 | 2018-02-22 |
Foreign References:
| US20100310534A1 | 2010-12-09 | |||
| US20170363629A1 | 2017-12-21 |
Other References:
BYUN KYUNG DO, HWANG HYO JUN, PARK KI JAE, KIM MIN CHAN, CHO SE HEON, JU MI HA, LEE JIN HWA, JEONG JIN SOOK: "T- Cell Immunoglobulin Mucin 3 Expression on Tumor Infiltrating Lymphocytes as a Positive Prognosticator in Triple-Negative Breast Cancer", J. BREAST CANCER, vol. 21, no. 4, December 2018 (2018-12-01), pages 406 - 414, XP055740574
VIKAS PRAVEEN, BORCHERDING NICHOLAS, ZHANG WEIZHOU: "The Clinical Promise of Immunotherapy in Triple-Negative Breast Cancer", CANCER MANAGEMENT AND RESEARCH, vol. 10, 2018, pages 6823 - 6833, XP055740578
SCIENCE, vol. 348, no. 6230, 3 April 2015 (2015-04-03), pages 62 - 8
VIKAS PRAVEEN, BORCHERDING NICHOLAS, ZHANG WEIZHOU: "The Clinical Promise of Immunotherapy in Triple-Negative Breast Cancer", CANCER MANAGEMENT AND RESEARCH, vol. 10, 2018, pages 6823 - 6833, XP055740578
SCIENCE, vol. 348, no. 6230, 3 April 2015 (2015-04-03), pages 62 - 8
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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