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Title:
MARKER SEQUENCES FOR MANAGING THE THERAPY OF RHEUMATOID ARTHRITIS PATIENTS
Document Type and Number:
WIPO Patent Application WO/2017/216323
Kind Code:
A2
Abstract:
The present invention relates to a method for managing the therapy of patients and patient (sub)populations (responder/non-responder) suffering from rheumatoid arthritis (RA) and to the use of suitable marker sequences, in particular in the form of panels, diagnostic agents and test kits, and to their use in rheumatoid arthritis (RA) diagnosis, prognosis and therapy management, in particular for drug-based therapy.

Inventors:
BUDDE PETRA (DE)
LÜKING ANGELIKA (DE)
SCHULZ-KNAPPE PETER (DE)
ZUCHT HANS-DIETER (DE)
Application Number:
PCT/EP2017/064728
Publication Date:
December 21, 2017
Filing Date:
June 15, 2017
Export Citation:
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Assignee:
PROTAGEN AG (DE)
International Classes:
G01N33/564; C07K17/00
Domestic Patent References:
WO2009030226A22009-03-12
WO1999057311A21999-11-11
WO1999057312A11999-11-11
Foreign References:
US5714389A1998-02-03
Other References:
DE GRUYTER: "Pschyrembel, 261. Auflage", 2007
J. SAMBROOK; E.F. FRITSCH; T. MANIATIS: "Molecular cloning: A laboratory manual, 2nd Edition,", 1989, COLD SPRING HABOR LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1989, GREEN PUBLISHING ASSOCIATES AND WILEY INTERSCIENCE
TERPE T, APPL MICROBIOL BIOTECHNOL., vol. 60, no. 5, January 2003 (2003-01-01), pages 523 - 33
SAMBROOK ET AL.: "Molecular Cloning, A laboratory handbook, 2nd edition", 1989, CSH PRESS
ALETAHA, D.; T. NEOGI ET AL.: "2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative", ANN RHEUM DIS, vol. 69, no. 9, 2010, pages 1580 - 1588
DETERT, J.; H. BASTIAN ET AL.: "Induction therapy with adalimumab plus methotrexate for 24weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study", ANN RHEUM DIS, vol. 72, no. 6, 2013, pages 844 - 850, XP055326809, DOI: doi:10.1136/annrheumdis-2012-201612
HUEBER, W.; B. TOMOOKA ET AL.: "Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis", ARTHRITIS RES THER, vol. 11, no. 3, 2009, pages R7 6, XP021061231, DOI: doi:10.1186/ar2706
SMOLEN, J. S., R. LANDEWE ET AL.: "EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs", ANN RHEUM DIS, vol. 69, no. 6, 2010, pages 964 - 975, XP055358292, DOI: doi:10.1136/ard.2009.126532
SOMERS, K.; P. GEUSENS ET AL.: "Novel autoantibody markers for early and seronegative rheumatoid arthritis", J AUTOIMMUN, vol. 36, no. 1, 2011, pages 33 - 46, XP028130655, DOI: doi:10.1016/j.jaut.2010.10.003
Attorney, Agent or Firm:
SIMANDI, Claus (DE)
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