Title:
MARKER TMEM43 FOR SENSORINEURAL HEARING LOSS DIAGNOSIS, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/078684
Kind Code:
A9
Abstract:
The present invention relates to marker TMEM43 for sensorineural hearing loss diagnosis, and a use thereof. Specifically, the present invention relates to: a composition for diagnosing sensorineural hearing loss containing a polynucleotide, which includes a continuous nucleotide sequence that is selected from among nucleotide sequences in an exon region of the TMEM43 gene in order to enable the detection of mutations of the TMEM43 gene, or a complementary polynucleotide thereof; and a method for detecting the mutation of genomic DNA in order to provide information for diagnosis. A kit or composition according to an aspect may be used to analyze the mutation of the TMEM43 gene with high sensitivity and accuracy, and sensorineural hearing loss may be efficiently diagnosed on the basis of the results of such an analysis.
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Inventors:
CHOI BYUNG YOON (KR)
OH DOO YI (KR)
LEE CHANGJOON JUSTIN (KR)
JANG MIN-WOO (KR)
OH SOO-JIN (KR)
OH DOO YI (KR)
LEE CHANGJOON JUSTIN (KR)
JANG MIN-WOO (KR)
OH SOO-JIN (KR)
Application Number:
PCT/KR2018/012442
Publication Date:
August 08, 2019
Filing Date:
October 19, 2018
Export Citation:
Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
KOREA INST SCI & TECH (KR)
KOREA INST SCI & TECH (KR)
International Classes:
C12Q1/6883; A01K67/027
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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