Title:
MARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND PRESYMPTOMATIC ALZHIMER'S DISEASE (PSAD)
Document Type and Number:
WIPO Patent Application WO/2015/048336
Kind Code:
A3
Abstract:
Methods to detect amyotrophic lateral sclerosis (ALS) or presymptomatic Alzheimer's disease (PSAD) using an indicator cell assay platform (iCAP) in a test subject are described. Specifically, the disclosure provides a method comprising contacting a biological fluid of said test subject with indicator cells and assessing said indicator cells for the level of expression of an exon of CKIgamma2 that encodes the C-terminal palmitoylated region of said CKIgamma2, to determine the probability that a test subject is afflicted with amyotrophic lateral sclerosis (ALS). Further disclosed are methods of using indicator cells that are pan neuronal populations of glutamatergic (and/or GABAergic) neurons to determine the probability of the presence of presymptomatic or symptomatic Alzheimer's disease (PSAD) in a test subject.
Inventors:
SMITH JENNIFER JOY (US)
DANZIGER SAMUEL ANTHONY (US)
AITCHISON JOHN DAVID (US)
MILLER LESLIE RAE (US)
DANZIGER SAMUEL ANTHONY (US)
AITCHISON JOHN DAVID (US)
MILLER LESLIE RAE (US)
Application Number:
PCT/US2014/057530
Publication Date:
May 28, 2015
Filing Date:
September 25, 2014
Export Citation:
Assignee:
INST SYSTEMS BIOLOGY (US)
International Classes:
C07H21/04; C12Q1/02; C12N5/00; C12Q1/68
Domestic Patent References:
| WO2003066086A2 | 2003-08-14 |
Foreign References:
| US20120245048A1 | 2012-09-27 | |||
| US20130029864A1 | 2013-01-31 |
Other References:
NAKAMURA ET AL.: "Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model.", ACTA NEUROPATHOL., vol. 115, no. 3, 2008, pages 327 - 34, XP019589268
GUO ET AL.: "Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-b signaling.", ONCOGENE, vol. 27, no. 58, 2008, pages 7235 - 7247, XP055329330
DATABASE GENBANK [online] 13 February 1997 (1997-02-13), "MP37H07.R1 BARSTEAD MPLRB1 MUS MUSCULUS CDNA CLONE", XP055329335, retrieved from NCBI Database accession no. AA109107.1
KNIPPSCHILD ET AL.: "The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development.", ONKOLOGIE, vol. 28, no. 10, 2005, pages 508 - 514, XP009130009
YIM ET AL.: "Unwinding the Wnt action of casein kinase 1.", CELL RES., vol. 23, no. 6, June 2013 (2013-06-01), pages 737 - 738, XP055329332
VAN HOECKE ET AL.: "EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.", NAT MED., vol. 18, no. 9, 2012, pages 1418 - 1422, XP055329333
GUO ET AL.: "Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-b signaling.", ONCOGENE, vol. 27, no. 58, 2008, pages 7235 - 7247, XP055329330
DATABASE GENBANK [online] 13 February 1997 (1997-02-13), "MP37H07.R1 BARSTEAD MPLRB1 MUS MUSCULUS CDNA CLONE", XP055329335, retrieved from NCBI Database accession no. AA109107.1
KNIPPSCHILD ET AL.: "The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development.", ONKOLOGIE, vol. 28, no. 10, 2005, pages 508 - 514, XP009130009
YIM ET AL.: "Unwinding the Wnt action of casein kinase 1.", CELL RES., vol. 23, no. 6, June 2013 (2013-06-01), pages 737 - 738, XP055329332
VAN HOECKE ET AL.: "EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.", NAT MED., vol. 18, no. 9, 2012, pages 1418 - 1422, XP055329333
Attorney, Agent or Firm:
ACKERMAN, Lily et al. (12531 High Bluff Drive Suite 10, San Diego CA, US)
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