Title:
MARKERS ASSOCIATED WITH WNT INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2014/141038
Kind Code:
A3
Abstract:
The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.
Inventors:
CHE JIANWEI (US)
HARRIS JENNIFER (US)
HSIN-I HSIEH MINDY (US)
LI JIE (US)
LIU JUN (US)
NG NICHOLAS (US)
HARRIS JENNIFER (US)
HSIN-I HSIEH MINDY (US)
LI JIE (US)
LIU JUN (US)
NG NICHOLAS (US)
Application Number:
PCT/IB2014/059585
Publication Date:
November 27, 2014
Filing Date:
March 10, 2014
Export Citation:
Assignee:
IRM LLC
CHE JIANWEI (US)
HARRIS JENNIFER (US)
HSIN-I HSIEH MINDY (US)
LI JIE (US)
LIU JUN (US)
NG NICHOLAS (US)
CHE JIANWEI (US)
HARRIS JENNIFER (US)
HSIN-I HSIEH MINDY (US)
LI JIE (US)
LIU JUN (US)
NG NICHOLAS (US)
International Classes:
A61P35/00; G01N33/574
Other References:
J. LIU ET AL: "PD08-11: Targeting Porcupine, a Critical Node for Wnt Signalling in Cancer.", CANCER RESEARCH, vol. 71, no. 24 Supplement, 15 December 2011 (2011-12-15), pages PD08 - 11, XP055061279, ISSN: 0008-5472, DOI: 10.1158/0008-5472.SABCS11-PD08-11
JAMIE N. ANASTAS ET AL: "WNT signalling pathways as therapeutic targets in cancer", NATURE REVIEWS CANCER, vol. 13, no. 1, 21 December 2012 (2012-12-21), pages 11 - 26, XP055121831, ISSN: 1474-175X, DOI: 10.1038/nrc3419
K. D. PROFFITT ET AL: "Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer", CANCER RESEARCH, vol. 73, no. 2, 27 November 2012 (2012-11-27), pages 502 - 507, XP055121070, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-12-2258
SHIH-MIN A. HUANG ET AL: "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling", NATURE, vol. 461, no. 7264, 16 September 2009 (2009-09-16), pages 614 - 620, XP055062115, ISSN: 0028-0836, DOI: 10.1038/nature08356
E CLAPPIER ET AL: "NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951", LEUKEMIA, vol. 24, no. 12, 23 September 2010 (2010-09-23), pages 2023 - 2031, XP055122043, ISSN: 0887-6924, DOI: 10.1038/leu.2010.205
KRISTEN R GEORGIOU ET AL: "Attenuated Wnt/ -catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats", BONE, PERGAMON PRESS., OXFORD, GB, vol. 50, no. 6, 22 March 2012 (2012-03-22), pages 1223 - 1233, XP028423829, ISSN: 8756-3282, [retrieved on 20120329], DOI: 10.1016/J.BONE.2012.03.027
FRED E. BERTRAND ET AL: "Developmental pathways in colon cancer: Crosstalk between WNT, BMP, Hedgehog and Notch", CELL CYCLE, vol. 11, no. 23, 1 December 2012 (2012-12-01), pages 4344 - 4351, XP055122055, ISSN: 1538-4101, DOI: 10.4161/cc.22134
AN-MING WANG ET AL: "The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 106, no. 4, 1 March 2009 (2009-03-01), pages 682 - 692, XP055122057, ISSN: 0730-2312, DOI: 10.1002/jcb.22065
YIMIN MA ET AL: "Inhibition of the Wnt-[beta]-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 431, no. 2, 1 February 2013 (2013-02-01), pages 274 - 279, XP055121072, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2012.12.118
J. LIU ET AL: "Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 50, 25 November 2013 (2013-11-25), pages 20224 - 20229, XP055121007, ISSN: 0027-8424, DOI: 10.1073/pnas.1314239110
N. J. WANG ET AL: "Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 43, 17 October 2011 (2011-10-17), pages 17761 - 17766, XP055122110, ISSN: 0027-8424, DOI: 10.1073/pnas.1114669108
S. FRE ET AL: "Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 15, 14 April 2009 (2009-04-14), pages 6309 - 6314, XP055122117, ISSN: 0027-8424, DOI: 10.1073/pnas.0900427106
JAMIE N. ANASTAS ET AL: "WNT signalling pathways as therapeutic targets in cancer", NATURE REVIEWS CANCER, vol. 13, no. 1, 21 December 2012 (2012-12-21), pages 11 - 26, XP055121831, ISSN: 1474-175X, DOI: 10.1038/nrc3419
K. D. PROFFITT ET AL: "Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer", CANCER RESEARCH, vol. 73, no. 2, 27 November 2012 (2012-11-27), pages 502 - 507, XP055121070, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-12-2258
SHIH-MIN A. HUANG ET AL: "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling", NATURE, vol. 461, no. 7264, 16 September 2009 (2009-09-16), pages 614 - 620, XP055062115, ISSN: 0028-0836, DOI: 10.1038/nature08356
E CLAPPIER ET AL: "NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951", LEUKEMIA, vol. 24, no. 12, 23 September 2010 (2010-09-23), pages 2023 - 2031, XP055122043, ISSN: 0887-6924, DOI: 10.1038/leu.2010.205
KRISTEN R GEORGIOU ET AL: "Attenuated Wnt/ -catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats", BONE, PERGAMON PRESS., OXFORD, GB, vol. 50, no. 6, 22 March 2012 (2012-03-22), pages 1223 - 1233, XP028423829, ISSN: 8756-3282, [retrieved on 20120329], DOI: 10.1016/J.BONE.2012.03.027
FRED E. BERTRAND ET AL: "Developmental pathways in colon cancer: Crosstalk between WNT, BMP, Hedgehog and Notch", CELL CYCLE, vol. 11, no. 23, 1 December 2012 (2012-12-01), pages 4344 - 4351, XP055122055, ISSN: 1538-4101, DOI: 10.4161/cc.22134
AN-MING WANG ET AL: "The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 106, no. 4, 1 March 2009 (2009-03-01), pages 682 - 692, XP055122057, ISSN: 0730-2312, DOI: 10.1002/jcb.22065
YIMIN MA ET AL: "Inhibition of the Wnt-[beta]-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 431, no. 2, 1 February 2013 (2013-02-01), pages 274 - 279, XP055121072, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2012.12.118
J. LIU ET AL: "Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 50, 25 November 2013 (2013-11-25), pages 20224 - 20229, XP055121007, ISSN: 0027-8424, DOI: 10.1073/pnas.1314239110
N. J. WANG ET AL: "Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 43, 17 October 2011 (2011-10-17), pages 17761 - 17766, XP055122110, ISSN: 0027-8424, DOI: 10.1073/pnas.1114669108
S. FRE ET AL: "Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 15, 14 April 2009 (2009-04-14), pages 6309 - 6314, XP055122117, ISSN: 0027-8424, DOI: 10.1073/pnas.0900427106
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