Title:
MARKERS FOR DETECTION OF COMPLICATIONS RESULTING FROM IN UTERO ENCOUTERS
Document Type and Number:
WIPO Patent Application WO/2010/087985
Kind Code:
A3
Abstract:
Described herein are biomarkers, such as protein biomarkers, which are diagnostic of and predictive for complications that result from an in utero encounter, such as an infection by the fetus, that can lead to premature birth (PTB). The biomarkers can be used to identify fetuses and newborns at risk for complications of PTB, such as (Early Onset Neonatal Sepsis) EONS, intra-ventricular hemorrhage (IVH) and other poor outcomes.
Inventors:
BUHIMSCHI CATALIN S (US)
BUHIMSCHI IRINA (US)
BHANDARI VINEET (US)
BUHIMSCHI IRINA (US)
BHANDARI VINEET (US)
Application Number:
PCT/US2010/000259
Publication Date:
December 09, 2010
Filing Date:
January 28, 2010
Export Citation:
Assignee:
UNIV YALE (US)
BUHIMSCHI CATALIN S (US)
BUHIMSCHI IRINA (US)
BHANDARI VINEET (US)
BUHIMSCHI CATALIN S (US)
BUHIMSCHI IRINA (US)
BHANDARI VINEET (US)
International Classes:
G01N33/68
Domestic Patent References:
| WO2008046160A1 | 2008-04-24 |
Foreign References:
| US20070161125A1 | 2007-07-12 |
Other References:
BUHIMSCHI CATALIN S ET AL: "COMPREHENSIVE PROTEOMIC MAPPING OF CORD BLOOD TO IDENTIFY NOVEL BIOMARKERS AND FUNCTIONAL PROTEIN NETWORKS CHARACTERISTIC OF EARLY ONSET NEONATAL SEPSIS (EONS)", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 199, no. 6, Suppl. 1, December 2008 (2008-12-01), & 29TH ANNUAL MEETING OF THE SOCIETY-FOR-MATERNAL-FETAL-MEDICINE; SAN DIEGO, CA, USA; JANUARY 26 -31, 2009, pages S3, XP002579425, ISSN: 0002-9378
BUHIMSCHI C ET AL: "504: Significance of early haptoglobin (HP) switching-on, levels and phenotypes in preterm newborns with early onset neonatal sepsis (EONS)", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 201, no. 6, 1 December 2009 (2009-12-01), pages S188 - S189, XP026797764, ISSN: 0002-9378, [retrieved on 20091201]
BUHIMSCHI C ET AL: "504: Significance of early haptoglobin (HP) switching-on, levels and phenotypes in preterm newborns with early onset neonatal sepsis (EONS)", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 201, no. 6, 1 December 2009 (2009-12-01), pages S188 - S189, XP026797764, ISSN: 0002-9378, [retrieved on 20091201]
Attorney, Agent or Firm:
GRANAHAN, Patricia (Greenfield & Sacks P.c.,600 Atlantic Avenu, Boston MA, US)
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