MASS SPECTROMETER AND BIOLOGICAL SAMPLE ANALYSIS METHOD USING SAID SPECTROMETER

Title:

MASS SPECTROMETER AND BIOLOGICAL SAMPLE ANALYSIS METHOD USING SAID SPECTROMETER

Document Type and Number:

WIPO Patent Application WO/2017/154240

Kind Code:

A1

Abstract:

In a PESI ion source, a solvent supply unit (8) is placed above the liver (101), which is the object of measurement, and by moving a probe (6) up and down such that the tip of the probe (6) passes through the solvent supply unit (8) and is inserted into the liver (101), a sample is captured by the tip of said probe. The solvent supply unit (8) includes a container unit comprising a liquid-blocking upper film body (81) stretched over the bottom surface opening of a cylindrical body (80), and a liquid-blocking lower film body (82) which is stretched out approximately in parallel with the upper film body (81) with a spacer interposed therebetween; the container unit houses a solvent (84). Because the tip of the probe (6) passes through the solvent (84) during the up-and-down movement of the probe (6), sufficient solvent adheres to the sample and when a high voltage is applied to the probe (6), components in the sample are favorably ionized. Blood seeping from the liver (101) upwards through the hole through which the probe (6) was passed spreads in the periphery of the lower film body (82) and is not admixed into the solvent (84) in the container unit. By this means, it is possible to avoid blood from acting as a contaminant during measurement.

More Like This:

JP2009193829	MS/MS MASS SPECTROSCOPE
JP4733704	Methods and compositions for measuring natriuretic peptides and their use
WO/2018/213435	STORAGE BIN VOLUME SENSOR WITH VOC SENSING SAFETY FEATURE

Inventors:

ZAITSU KEI (JP)
HAYASHI YUMI (JP)
MURATA TASUKU (JP)

Application Number:

PCT/JP2016/075064

Publication Date:

September 14, 2017

Filing Date:

August 26, 2016

Export Citation:

Click for automatic bibliography generation Help

Assignee:

SHIMADZU CORP (JP)
NAT UNIV CORP NAGOYA UNIV (JP)

International Classes:

G01N27/62; H01J49/10

Domestic Patent References:

WO2007126141A1	2007-11-08
WO2016027319A1	2016-02-25

Foreign References:

JP2014044110A

2014-03-13

Other References:

ZAITSU,K., ANAL.CHEM., vol. 88, 9 March 2016 (2016-03-09), pages 3556 - 3561

Attorney, Agent or Firm:

KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: MOTOR DRIVE DEVICE AND METHOD FOR DETECTING PHASE CURRENT IN MOTOR DRIVE DEVICE

Next Patent: ANOMALY DETECTION DEVICE AND ANOMALY DETECTION METHOD