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Title:
MASS SPECTROMETER AND BIOLOGICAL SAMPLE ANALYSIS METHOD USING SAID SPECTROMETER
Document Type and Number:
WIPO Patent Application WO/2017/154240
Kind Code:
A1
Abstract:
In a PESI ion source, a solvent supply unit (8) is placed above the liver (101), which is the object of measurement, and by moving a probe (6) up and down such that the tip of the probe (6) passes through the solvent supply unit (8) and is inserted into the liver (101), a sample is captured by the tip of said probe. The solvent supply unit (8) includes a container unit comprising a liquid-blocking upper film body (81) stretched over the bottom surface opening of a cylindrical body (80), and a liquid-blocking lower film body (82) which is stretched out approximately in parallel with the upper film body (81) with a spacer interposed therebetween; the container unit houses a solvent (84). Because the tip of the probe (6) passes through the solvent (84) during the up-and-down movement of the probe (6), sufficient solvent adheres to the sample and when a high voltage is applied to the probe (6), components in the sample are favorably ionized. Blood seeping from the liver (101) upwards through the hole through which the probe (6) was passed spreads in the periphery of the lower film body (82) and is not admixed into the solvent (84) in the container unit. By this means, it is possible to avoid blood from acting as a contaminant during measurement.

Inventors:
ZAITSU, Kei (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
HAYASHI, Yumi (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
MURATA, Tasuku (1 Nishinokyo-Kuwabara-cho, Nakagyo-ku, Kyoto-sh, Kyoto 11, 〒6048511, JP)
Application Number:
JP2016/075064
Publication Date:
September 14, 2017
Filing Date:
August 26, 2016
Export Citation:
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Assignee:
SHIMADZU CORPORATION (1 Nishinokyo-Kuwabara-cho, Nakagyo-ku Kyoto-sh, Kyoto 11, 〒6048511, JP)
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (1 Furo-cho, Chikusa-ku Nagoya-sh, Aichi 01, 〒4648601, JP)
International Classes:
G01N27/62; H01J49/10
Domestic Patent References:
WO2007126141A12007-11-08
WO2016027319A12016-02-25
Foreign References:
JP2014044110A2014-03-13
Other References:
ZAITSU,K., ANAL.CHEM., vol. 88, 9 March 2016 (2016-03-09), pages 3556 - 3561
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (Hougen-Sizyokarasuma Building, 37 Motoakuozi-tyo, Higasinotouin Sizyo-sagaru, Simogyo-ku, Kyoto-s, Kyoto 91, 〒6008091, JP)
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