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Document Type and Number:
WIPO Patent Application WO/2017/183086
Kind Code:
An image formation optical system (15) having a small focal distance and an aperture member (14) having an opening having a predetermined shape are disposed in a predetermined position between a laser irradiation part (13) and a sample (100), and a substantially square-shaped laser light irradiation region is formed by forming a reduced image of the opening shape on the sample (100). A configuration is adopted whereby the aperture member (14) and the image formation optical system (15) can each be moved in the optical axis direction, and the size of the substantially square-shaped laser light irradiation region on the sample (100) is variable. The size of the laser light irradiation region is matched to the size of a unit region of interest in an analysis object region on the sample (100), and a step width of scanning for moving the laser light irradiation position is also matched to the size of the unit region of interest, whereby the sample (100) can be evenly scanned and mass spectrometry data can be collected without overlapping of laser irradiation sites. The sample can thereby be effectively utilized, mass detection omission is eliminated, and the uniformity of signal strength of a uniformly distributed mass is also increased.

HARADA, Takahiro (1 Nishinokyo-Kuwabara-cho, Nakagyo-ku, Kyoto-sh, Kyoto 11, 〒6048511, JP)
Application Number:
Publication Date:
October 26, 2017
Filing Date:
April 18, 2016
Export Citation:
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SHIMADZU CORPORATION (1 Nishinokyo-Kuwabara-cho, Nakagyo-ku Kyoto-sh, Kyoto 11, 〒6048511, JP)
International Classes:
G01N27/62; H01J49/10
Domestic Patent References:
Foreign References:
Other References:
KETTLING H., ET AL.: "MALDI Mass Spectrometry Imaging of Bioactive Lipids in Mouse Brain with a Synapt G2-S Mass Spectrometer Operated at Elevated Pressure: Improving the Analytical Sensitivity and the Lateral Resolution to Ten Micrometers", ANALYTICAL CHEMISTRY, vol. 86, no. 15, 9 July 2014 (2014-07-09), pages 7798 - 7805, XP055548109
See also references of EP 3447485A4
HARADA ET AL.: "Biological Tissue Analysis with Microscopic Mass Spectrometer", SHIMADZU REVIEW, SHIMADZU REVIEW EDITORIAL DEPARTMENT, vol. 64, no. 3, 4, 2007
"rapiflex XTm MALDI Tissuetyper™", 16 March 2016, BRUKER INC.
J. C. JURCHEN ET AL.: "MALDI-MS Imaging of Features Smaller than the Size of the Laser Beam", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 16, no. 10, 2005, pages 1654 - 1659, XP025302913, DOI: doi:10.1016/j.jasms.2005.06.006
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (Hougen-Sizyokarasuma Building, 37 Motoakuozi-tyo, Higasinotouin Sizyo-sagaru, Simogyo-ku, Kyoto-s, Kyoto 91, 〒6008091, JP)
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