Title:
MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD
Document Type and Number:
WIPO Patent Application WO/2022/201705
Kind Code:
A1
Abstract:
Precursor cations are reacted with ammonium molecules or ammonia radicals to generate product ions, the product ions are separated and detected on the basis of mass-to-charge ratio, and on the basis of the difference between the detected mass-to-charge ratio of the product ions and the mass-to-charge ratio of the precursor ions, it is estimated whether or not aldehyde groups are contained in the molecular structure of the precursor ions. Further, this mass spectrometry device (1) is provided with: a reaction chamber (132) where precursor ions are introduced, an ammonia supply unit (5) which supplies ammonia molecules or ammonia radicals to the reaction chamber, and separation detection units (142, 143, 144, 145) which, on the basis of the mass-to-charge ratio, separate and detect the product ions generated from the precursor ions by reaction with the ammonia molecules or ammonia radicals.
Inventors:
TAKAHASHI HIDENORI (JP)
Application Number:
PCT/JP2021/047972
Publication Date:
September 29, 2022
Filing Date:
December 23, 2021
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N27/62
Domestic Patent References:
| WO2015133259A1 | 2015-09-11 | |||
| WO2019155725A1 | 2019-08-15 | |||
| WO2015133259A1 | 2015-09-11 | |||
| WO2018186286A1 | 2018-10-11 | |||
| WO2019155725A1 | 2019-08-15 | |||
| WO2020240908A1 | 2020-12-03 |
Foreign References:
| JP2012514337A | 2012-06-21 | |||
| JP2020177784A | 2020-10-29 |
Other References:
WITKOWSKI BARTŁOMIEJ, GIERCZAK TOMASZ: "Analysis of α-acyloxyhydroperoxy aldehydes with electrospray ionization-tandem mass spectrometry (ESI-MS n ) : Analysis of alpha-acyloxyhydroperoxy aldehydes", JOURNAL OF MASS SPECTROMETRY, WILEY CHICHESTER, GB, vol. 48, no. 1, 1 January 2013 (2013-01-01), GB , pages 79 - 88, XP055970813, ISSN: 1076-5174, DOI: 10.1002/jms.3130
HIDENORI TAKAHASHIYUJI SHIMABUKURODAIKI ASAKAWAAKIHITO KORENAGAMASAKI YAMADASHINICHI IWAMOTOMOTOI WADAKOICHI TANAKA: "Identifying Double Bond Positions in Phospholipids Using Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry Based on Oxygen Attachment Dissociation", MASS SPEDCTROMETRY, vol. 8, 2020, pages S0080, XP055944331, DOI: 10.5702/massspectrometry.S0080
WOLF, S.SCHMIDT, S.MULLER-HANNEMANN, M.NEUMANN, S.: "In silico fragmentation for computer assisted identification of metabolite mass spectra", BMC BIOINFORMATICS, vol. 11, 2010, pages 148, XP021071491, DOI: 10.1186/1471-2105-11-148
HIDENORI TAKAHASHIYUJI SHIMABUKURODAIKI ASAKAWAAKIHITO KORENAGAMASAKI YAMADASHINICHI IWAMOTOMOTOI WADAKOICHI TANAKA: "Identifying Double Bond Positions in Phospholipids Using Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry Based on Oxygen Attachment Dissociation", MASS SPEDCTROMETRY, vol. 8, 2020, pages S0080, XP055944331, DOI: 10.5702/massspectrometry.S0080
WOLF, S.SCHMIDT, S.MULLER-HANNEMANN, M.NEUMANN, S.: "In silico fragmentation for computer assisted identification of metabolite mass spectra", BMC BIOINFORMATICS, vol. 11, 2010, pages 148, XP021071491, DOI: 10.1186/1471-2105-11-148
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
Download PDF: