Title:
MASSIVELY PARALLEL COMBINATORIAL GENETICS FOR CRISPR
Document Type and Number:
WIPO Patent Application WO/2016/070037
Kind Code:
A8
Abstract:
Described herein are methods and compositions that enable rapid generation of high-order combinations of genetic elements comprising a CRISPR guide sequence and a scaffold sequence, and a barcode for rapid identification of the combination of genetic elements encoded within a single cell or a pooled population. Also described herein compositions of inhibitors of epigenetic genes and methods for reducing cell proliferation and/or treating cancer.
Inventors:
LU TIMOTHY KUAN-TA (US)
WONG ALAN SIU LUN (US)
CHOI CHING GEE (US)
WONG ALAN SIU LUN (US)
CHOI CHING GEE (US)
Application Number:
PCT/US2015/058304
Publication Date:
March 02, 2017
Filing Date:
October 30, 2015
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
C12N15/10
Attorney, Agent or Firm:
DIPIETRANTONIO, Heather, J. (US)
Download PDF:
Previous Patent: A SYSTEM AND METHOD FOR PERFORMING A WET ETCHING PROCESS
Next Patent: LINEAR ACTUATOR FOR MOTION SIMULATOR
Next Patent: LINEAR ACTUATOR FOR MOTION SIMULATOR