MATCHED FILTRATION WITH EXPERIMENTAL NOISE DETERMINATION FOR DENOISING, PEAK PICKING AND QUANTITATION IN LC-MS

Title:

MATCHED FILTRATION WITH EXPERIMENTAL NOISE DETERMINATION FOR DENOISING, PEAK PICKING AND QUANTITATION IN LC-MS

Document Type and Number:

WIPO Patent Application WO2003087770

Kind Code:

A3

Abstract:

An improved system and method of analyzing sample data that increases the reliability of peak (compound) detection and identification in the presence of chemical and/or random noise. The sample analysis system includes a compound-separating unit for separating constituent compounds in a sample mixture, a compound-analyzing unit for identifying and quantitating at least one of the separated compounds, and a computer for acquiring data from the compound-separating and compound-analyzing units, for generating a multi-dimensional data set incorporating the acquired data, for executing an algorithm for reducing noise in the data set and for detecting peaks (compounds) in the noise-reduced data set, and for identifying/quantitating the detected compounds.

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Inventors:

ANDREEV VICTOR P (US)
REJTAR TOMAS (US)
KARGER BARRY L (US)

Application Number:

PCT/US2003/011193

Publication Date:

June 16, 2005

Filing Date:

April 11, 2003

Export Citation:

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Assignee:

UNIV NORTHEASTERN (US)
ANDREEV VICTOR P (US)
REJTAR TOMAS (US)
KARGER BARRY L (US)

International Classes:

G06F19/00; G01N; (IPC1-7): G06F19/00

Foreign References:

US5668373A	1997-09-16
US5995989A	1999-11-30

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