Title:
MATERIAL FOR SCREENING FOR COMPOUND CAPABLE OF ACTING ON ION CHANNEL, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/002460
Kind Code:
A1
Abstract:
Disclosed is a screening system which targets an ion channel and has excellent efficiency. Specifically disclosed is a material for use in the screening of a compound capable of acting on a target ion channel, which comprises a cell that carries at least one first DNA encoding a voltage-dependent Na ion channel that cannot be inactivated, wherein a K ion channel in the cell is so activated that the depth of the resting membrane potential is increased gradually in the negative direction.
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Inventors:
IMAIZUMI YUJI (JP)
FUJII MASATO (JP)
OHYA SUSUMU (JP)
YAMAMURA HISAO (JP)
FUJII MASATO (JP)
OHYA SUSUMU (JP)
YAMAMURA HISAO (JP)
Application Number:
PCT/JP2011/064967
Publication Date:
January 05, 2012
Filing Date:
June 29, 2011
Export Citation:
Assignee:
PUBLIC UNIV CORP NAGOYA CITY UNIV (JP)
CHANNELOSEARCH TECHNOLOGY (JP)
IMAIZUMI YUJI (JP)
FUJII MASATO (JP)
OHYA SUSUMU (JP)
YAMAMURA HISAO (JP)
CHANNELOSEARCH TECHNOLOGY (JP)
IMAIZUMI YUJI (JP)
FUJII MASATO (JP)
OHYA SUSUMU (JP)
YAMAMURA HISAO (JP)
International Classes:
C12Q1/02; C12M1/34; C12N15/09
Foreign References:
| JP2006126073A | 2006-05-18 |
Other References:
SAITO ET AL.: "ES Saibo o Tsukatta Soyaku, Screening Business ni Tsuite (ES cells for Drug Discovery)", GEKKAN MEDICAL SCIENCE DIGEST, 12 GATSU SPECIAL EXTRA, vol. 33, no. 14, 25 December 2007 (2007-12-25), pages 33 - 36, XP008142323
MOHAN D.K. ET AL.: "Toxin detection based on action potential shape analysis using a realistic mathematical model of differentiated NG108-15 cells", BIOSENSORS AND BIOELECTRONICS, vol. 21, 15 March 2006 (2006-03-15), pages 1804 - 1811, XP024961482
WALLIS, R.M ET AL.: "Non Clinical Pharmacology -To Cover Testing Paradigms and Latest ICH Thinking (ICH S7B)", SHIN'YAKU NO KAIHATSU SENRYAKU SAIZENSEN, vol. 31, no. SUPPL, 25 June 2004 (2004-06-25), pages 279 - 295
MASATO FUJII ET AL.: "Kaihen Idenshi Hatsugen Saibo o Mochiita Saiboshi Sokutei ni yoru Shinki Ion Channel Hyoteki Soyaku Screening-kei no Kaihatsu", DAI 118 KAI THE JAPANESE PHARMACOLOGICAL SOCIETY KINKI BUKAI PROGRAM YOSHISHU, 19 November 2010 (2010-11-19), pages 60, C-15
MASATO FUJII ET AL.: "Kaihen Idenshi Hatsugen Saibo o Mochiita Saiboshi Sokutei ni yoru Shinki Ion Channel Hyoteki Soyaku Screening-kei no Kaihatsu", THE PHARMACEUTICAL SOCIETY OF JAPAN DAI 131 NENKAI YOSHISHU 3, 5 March 2011 (2011-03-05), pages 81
TIM J.; DALE ET AL., MOL. BIOSYST, vol. 3, 2007, pages 714 - 722
A.O. GRANT ET AL., BIOPHYS. J., vol. 79, 2000, pages 3019 - 3035
M.M. MCNULTY ET AL., MOL. PHARMACOL., vol. 70, 2006, pages 1514 - 1523
D.E. PATTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 10905 - 10909
WEST J.W. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 10910 - 10914
L.Q. CHEN ET AL., J. GEN- PHYSIOL., vol. 108, 1996, pages 549 - 556
CIRC. RES., vol. 94, 2004, pages 1332 - 1339
AM. J. PHYSIOL. CELL PHYSIOL., vol. 289, 2005, pages C1134 - C1144
J. BIOL. CHEM., vol. 278, no. 50, 2003, pages 50654 - 50663
EMBO J., vol. 17, no. 12, 1998, pages 3290 - 3296
VA CAMPANUCCI ET AL., NEUROSCIENCE, vol. 135, 2005, pages 1087 - 1094
C. KINDLER ET AL., J. PHARMACOL. EXP. THER., vol. 306, 2003, pages 84 - 92
S.S. MCDANIEL ET AL., J. APPL. PHYSIOL., vol. 91, 2001, pages 2322 - 2333
CELL. BIOCHEM. BIOPHYS., vol. 47, 2007, pages 209 - 25
See also references of EP 2589664A4
MOHAN D.K. ET AL.: "Toxin detection based on action potential shape analysis using a realistic mathematical model of differentiated NG108-15 cells", BIOSENSORS AND BIOELECTRONICS, vol. 21, 15 March 2006 (2006-03-15), pages 1804 - 1811, XP024961482
WALLIS, R.M ET AL.: "Non Clinical Pharmacology -To Cover Testing Paradigms and Latest ICH Thinking (ICH S7B)", SHIN'YAKU NO KAIHATSU SENRYAKU SAIZENSEN, vol. 31, no. SUPPL, 25 June 2004 (2004-06-25), pages 279 - 295
MASATO FUJII ET AL.: "Kaihen Idenshi Hatsugen Saibo o Mochiita Saiboshi Sokutei ni yoru Shinki Ion Channel Hyoteki Soyaku Screening-kei no Kaihatsu", DAI 118 KAI THE JAPANESE PHARMACOLOGICAL SOCIETY KINKI BUKAI PROGRAM YOSHISHU, 19 November 2010 (2010-11-19), pages 60, C-15
MASATO FUJII ET AL.: "Kaihen Idenshi Hatsugen Saibo o Mochiita Saiboshi Sokutei ni yoru Shinki Ion Channel Hyoteki Soyaku Screening-kei no Kaihatsu", THE PHARMACEUTICAL SOCIETY OF JAPAN DAI 131 NENKAI YOSHISHU 3, 5 March 2011 (2011-03-05), pages 81
TIM J.; DALE ET AL., MOL. BIOSYST, vol. 3, 2007, pages 714 - 722
A.O. GRANT ET AL., BIOPHYS. J., vol. 79, 2000, pages 3019 - 3035
M.M. MCNULTY ET AL., MOL. PHARMACOL., vol. 70, 2006, pages 1514 - 1523
D.E. PATTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 10905 - 10909
WEST J.W. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 10910 - 10914
L.Q. CHEN ET AL., J. GEN- PHYSIOL., vol. 108, 1996, pages 549 - 556
CIRC. RES., vol. 94, 2004, pages 1332 - 1339
AM. J. PHYSIOL. CELL PHYSIOL., vol. 289, 2005, pages C1134 - C1144
J. BIOL. CHEM., vol. 278, no. 50, 2003, pages 50654 - 50663
EMBO J., vol. 17, no. 12, 1998, pages 3290 - 3296
VA CAMPANUCCI ET AL., NEUROSCIENCE, vol. 135, 2005, pages 1087 - 1094
C. KINDLER ET AL., J. PHARMACOL. EXP. THER., vol. 306, 2003, pages 84 - 92
S.S. MCDANIEL ET AL., J. APPL. PHYSIOL., vol. 91, 2001, pages 2322 - 2333
CELL. BIOCHEM. BIOPHYS., vol. 47, 2007, pages 209 - 25
See also references of EP 2589664A4
Attorney, Agent or Firm:
KAI-U PATENT LAW FIRM (JP)
Patent business corporation KAI-U Patent Law Firm (JP)
Patent business corporation KAI-U Patent Law Firm (JP)
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