Title:
MATERIALS HAVING CROSSLINKED POLYROTAXANE AND PROCESS FOR PRODUCING THESE
Document Type and Number:
WIPO Patent Application WO/2005/108464
Kind Code:
A1
Abstract:
A material having a crosslinked polyrotaxane which has further improved swelling properties, especially one having a crosslinked polyrotaxane which changes in swelling property with changing pH; and a material having a crosslinked polyrotaxane which is responsive especially at a high speed to a change of the surrounding electric field. The materials have a crosslinked polyrotaxane comprising at least two polyrotaxane molecules which each comprises cyclic molecules, a linear molecule which pierces through the spaces in the cyclic molecules to form a clathrate therewith, and blocking groups disposed respectively at both ends of the linear molecule so as to prevent the cyclic molecules from separating therefrom, the at least two polyrotaxane molecules having been bonded to each other through chemical bonds between the cyclic molecules thereof, wherein the cyclic molecules have hydroxy groups (-OH) and part of the hydroxy groups are replaced with a group having an ionic group.
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Inventors:
ITO KOHZO (JP)
ARAKI JUN (JP)
ARAKI JUN (JP)
Application Number:
PCT/JP2005/008346
Publication Date:
November 17, 2005
Filing Date:
May 06, 2005
Export Citation:
Assignee:
ITO KOHZO (JP)
ARAKI JUN (JP)
ARAKI JUN (JP)
International Classes:
A61K47/32; A61K47/34; A61K47/40; B01J20/24; B01J20/26; C08B37/00; C08B37/16; C08G65/30; C08G65/329; C08G65/48; C08G85/00; C08L71/02; (IPC1-7): C08G65/329; B01J20/24; C08B37/16; C08G65/30; C08L71/02
Domestic Patent References:
| WO2001083566A1 | 2001-11-08 | |||
| WO2003074099A1 | 2003-09-12 | |||
| WO2002002159A1 | 2002-01-10 |
Foreign References:
| JP2004027183A | 2004-01-29 | |||
| JP2810264B2 | 1998-10-15 | |||
| JP3475252B2 | 2003-12-08 | |||
| US5538655A | 1996-07-23 | |||
| EP1283218A1 | 2003-02-12 | |||
| EP1710269A1 | 2006-10-11 | |||
| EP1707587A1 | 2006-10-04 | |||
| EP1801199A1 | 2007-06-27 | |||
| US20040157989A1 | 2004-08-12 |
Other References:
ICHI T ET AL: "Polyrotaxane o Kihon Kokkaku toshita 3-Jigen Soshikitai no Chosei to sono Tokusei Kaiseki.", THE JAPAN SOCIETY OF MECHANICAL ENGINEERS., 5 January 2000 (2000-01-05), pages 217 - 218, XP002994417
OKUMURA Y ET AL: "The Polyrotaxane Gel: A topological Gel by Figure-of-Eight Cross-links.", ADVANCED MATERIALS., vol. 13, no. 7, 4 April 2001 (2001-04-04), pages 485 - 487, XP001044104
See also references of EP 1749849A4
YOON KI JOUNG ET AL.: "Anticoagulant supramolecular-strucutred polymers: Synthesis and anti coagulant activity of taurine-conjugated carboxyethylester-polyrotaxanes", SCI. TECHNOL. ADV. MAT., vol. 6, 2005, pages 484 - 90
JUNJ I WATANABE ET AL.: "Effect of acetylation of biodegradable polyrotaxanes on its supramolecular dissociation via terminal ester hydrolysis", J. BIOMAT. SCI.-POLYM. E., vol. 10, 1999, pages 1275 - 88, XP002969569
HYUNG DAL PARK ET AL.: "In vitro biocompatibility assessment of sulfonatedpolyrotaxane-immobilizedpolyurethane surfaces", J. BIOMED. MATER. RES., vol. 66A, 2003, pages 596 - 604
HYUNG DAL PARK ET AL.: "Anticoagulant activity of sulfonated polyrotaxanes as blood-compatible materials", J. BIOMED. MATER. RES., vol. 60, 2002, pages 186 - 90, XP002487693
TOORU OOYA ET AL.: "Supramolecular Design for Multivalent Interaction: Maltose Mobility along Polyrotaxane Enhanced Binding with Concanavalin A", J. AM. CHEM. SOC., vol. 125, 2003, pages 13016 - 7, XP002523161, DOI: doi:10.1021/JA034583Z
TAKAHIRO ICHI ET AL.: "Polyrotaxane o Kihon Kokkaku toshita 3-Jigen Soshikitai no Chosei to sono Tokusei Kaiseki. /Preparation and Characterization of Three-Dimensional Architecture Based on Polyrotaxane Structure", JOURNAL OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS, 2000, pages 217 - 8
YASUSHI OKUMURA ET AL.: "The Polyrotaxane Gel: A Topological Gel by Figure-of-Eight Cross-links", ADV. MATER., vol. 13, 2001, pages 485 - 7, XP001044104, DOI: doi:10.1002/1521-4095(200104)13:7<485::AID-ADMA485>3.0.CO;2-T
OKUMURA Y ET AL: "The Polyrotaxane Gel: A topological Gel by Figure-of-Eight Cross-links.", ADVANCED MATERIALS., vol. 13, no. 7, 4 April 2001 (2001-04-04), pages 485 - 487, XP001044104
See also references of EP 1749849A4
YOON KI JOUNG ET AL.: "Anticoagulant supramolecular-strucutred polymers: Synthesis and anti coagulant activity of taurine-conjugated carboxyethylester-polyrotaxanes", SCI. TECHNOL. ADV. MAT., vol. 6, 2005, pages 484 - 90
JUNJ I WATANABE ET AL.: "Effect of acetylation of biodegradable polyrotaxanes on its supramolecular dissociation via terminal ester hydrolysis", J. BIOMAT. SCI.-POLYM. E., vol. 10, 1999, pages 1275 - 88, XP002969569
HYUNG DAL PARK ET AL.: "In vitro biocompatibility assessment of sulfonatedpolyrotaxane-immobilizedpolyurethane surfaces", J. BIOMED. MATER. RES., vol. 66A, 2003, pages 596 - 604
HYUNG DAL PARK ET AL.: "Anticoagulant activity of sulfonated polyrotaxanes as blood-compatible materials", J. BIOMED. MATER. RES., vol. 60, 2002, pages 186 - 90, XP002487693
TOORU OOYA ET AL.: "Supramolecular Design for Multivalent Interaction: Maltose Mobility along Polyrotaxane Enhanced Binding with Concanavalin A", J. AM. CHEM. SOC., vol. 125, 2003, pages 13016 - 7, XP002523161, DOI: doi:10.1021/JA034583Z
TAKAHIRO ICHI ET AL.: "Polyrotaxane o Kihon Kokkaku toshita 3-Jigen Soshikitai no Chosei to sono Tokusei Kaiseki. /Preparation and Characterization of Three-Dimensional Architecture Based on Polyrotaxane Structure", JOURNAL OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS, 2000, pages 217 - 8
YASUSHI OKUMURA ET AL.: "The Polyrotaxane Gel: A Topological Gel by Figure-of-Eight Cross-links", ADV. MATER., vol. 13, 2001, pages 485 - 7, XP001044104, DOI: doi:10.1002/1521-4095(200104)13:7<485::AID-ADMA485>3.0.CO;2-T
Attorney, Agent or Firm:
Inami, Minoru (INABA & INAMI Hanabishi Imas Hirakawacho
Building, 4th Floor, 3-11, Hirakawacho, 2-chom, Chiyoda-ku Tokyo 93, JP)
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