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Title:
MATRIX METALLOPROTEASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2002/006227
Kind Code:
A1
Abstract:
The present invention provides matrix metalloprotease (MMP) inhibitors improved in the retention at an affected part of a living body. Specifically, cationic matrix metalloprotease inhibitors bearing cationic groups in the molecule or salts thereof are provided.

Inventors:
OKAMACHI AKIRA (JP)
TAMURA TATSUYA (JP)
HAYASHI YOSHIKI (JP)
NAKAMURA TERUO (JP)
Application Number:
PCT/JP2001/006172
Publication Date:
January 24, 2002
Filing Date:
July 17, 2001
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
OKAMACHI AKIRA (JP)
TAMURA TATSUYA (JP)
HAYASHI YOSHIKI (JP)
NAKAMURA TERUO (JP)
International Classes:
A61K38/55; A61P19/02; A61P29/00; A61P43/00; C07D209/20; (IPC1-7): C07D209/20; A61K31/405; A61K38/05; A61K38/06; A61K38/07; A61P19/02; A61P29/00; A61P43/00
Domestic Patent References:
WO1999002510A11999-01-21
WO1997049674A11997-12-31
WO1999031052A11999-06-24
WO1998026773A11998-06-25
WO1997043250A11997-11-20
WO1997035538A21997-10-02
WO1997026257A11997-07-24
WO1997015553A11997-05-01
WO1996033968A11996-10-31
WO1995006031A11995-03-02
WO1995004033A11995-02-09
WO1994010990A11994-05-26
WO1993024449A11993-12-09
WO2000003734A12000-01-27
WO2000003703A12000-01-27
WO1992013831A11992-08-20
WO1992009564A11992-06-11
Foreign References:
JP2001055327A2001-02-27
JPH111430A1999-01-06
EP0274453A21988-07-13
EP0231081A21987-08-05
Attorney, Agent or Firm:
Shamoto, Ichio (New Ohtemachi Bldg. 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)
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