MDA-7/IL SECRETORY VARIANTS AND METHODS OF USE

Title:

MDA-7/IL SECRETORY VARIANTS AND METHODS OF USE

Document Type and Number:

WIPO Patent Application WO/2019/147623

Kind Code:

A3

Abstract:

In various aspects, the present disclosure provides polynucleotides encoding a fusion protein, as well as vectors, cells, and compositions comprising the same. In embodiments, the fusion protein includes an insulin signal peptide and an MDA-7/IL-24 protein. Methods of using the polynucleotides, vectors, cells, and compositions, such as in the treatment or prevention of cancer, are also provided.

Inventors:

FISHER PAUL (US)
MENEZES MITCHELL (US)
BHOOPATHI PRAVEEN (US)
DAS SWADESH (US)
EMDAD LUNI (US)
SARKAR DEVANAND (US)
PRADHAN ANJAN (US)
WANG XIANG-YANG (US)

Application Number:

PCT/US2019/014686

Publication Date:

October 31, 2019

Filing Date:

January 23, 2019

Export Citation:

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Assignee:

UNIV VIRGINIA COMMONWEALTH (US)
FISHER PAUL B (US)
MENEZES MITCHELL E (US)
BHOOPATHI PRAVEEN (US)
DAS SWADESH K (US)
EMDAD LUNI (US)
SARKAR DEVANAND (US)
PRADHAN ANJAN K (US)
WANG XIANG YANG (US)

International Classes:

A61K38/17; A61K39/395; A61K48/00; C07H21/04; C07K14/82; C07K16/30

Foreign References:

US20060292157A1	2006-12-28
US20060062772A1	2006-03-23
US20140235702A1	2014-08-21
US20120237533A1	2012-09-20
US20070009484A1	2007-01-11
US20090053244A1	2009-02-26

Other References: