Title:
MEANS AND METHODS FOR TREATING COPPER-RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2017/103094
Kind Code:
A3
Abstract:
The present invention relates to the field of (bio-)medicine, and more particularly to the treatment of copper-related diseases. Novel means and methods for depleting (excess) copper from organs and/or the circulation are provided. Agents with a high copper binding affinity and stabilized forms thereof are provided, as well as a novel treatment regimen. The means and methods of the present invention are particularly useful for treatment of Wilson Disease, but also for treatment of other conditions.
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Inventors:
ZISCHKA HANS (DE)
LICHTMANNEGGER JOSEF (DE)
DISPIRITO ALAN ANGELO (US)
SEMRAU JEREMY DAVID (US)
LICHTMANNEGGER JOSEF (DE)
DISPIRITO ALAN ANGELO (US)
SEMRAU JEREMY DAVID (US)
Application Number:
PCT/EP2016/081407
Publication Date:
July 27, 2017
Filing Date:
December 16, 2016
Export Citation:
Assignee:
HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (DE)
UNIV MICHIGAN REGENTS (US)
UNIV IOWA STATE RES FOUND INC (US)
UNIV MICHIGAN REGENTS (US)
UNIV IOWA STATE RES FOUND INC (US)
International Classes:
A61K31/315; A61K31/30; A61K31/4166; A61K38/00; A61P1/16
Domestic Patent References:
| WO2004056849A2 | 2004-07-08 |
Foreign References:
| US8735538B1 | 2014-05-27 |
Other References:
KARL H SUMMER ET AL: "The biogenic methanobactin is an effective chelator for copper in a rat model for Wilson disease", JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, FISCHER, NEW YORK, NY, US, vol. 25, no. 1, 8 December 2010 (2010-12-08), pages 36 - 41, XP028165079, ISSN: 0946-672X, [retrieved on 20101213], DOI: 10.1016/J.JTEMB.2010.12.002
GRACE E. KENNEY ET AL: "Chemistry and Biology of the Copper Chelator Methanobactin", ACS CHEMICAL BIOLOGY, vol. 7, no. 2, 17 February 2012 (2012-02-17), US, pages 260 - 268, XP055307727, ISSN: 1554-8929, DOI: 10.1021/cb2003913
M.-L. PESCH ET AL: "Competitive ligand exchange between Cu-humic acid complexes and methanobactin", GEOBIOLOGY, vol. 11, no. 1, 22 January 2013 (2013-01-22), pages 44 - 54, XP055307717, ISSN: 1472-4677, DOI: 10.1111/gbi.12010
MARIE-LAURE PESCH ET AL: "Copper complexation of methanobactin isolated from Methylosinus trichosporium OB3b: pH-dependent speciation and modeling", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 116, 1 November 2012 (2012-11-01), US, pages 55 - 62, XP055307730, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2012.07.008
CHOI D W ET AL: "Spectral and thermodynamic properties of Ag(I), Au(III), Cd(II), Co(II), Fe(III), Hg(II), Mn(II), Ni(II), Pb(II), U(IV), and Zn(II) binding by methanobactin from Methylosinus trichosporium OB3b", JOURNAL OF INORGANIC BIOCHEMISTRY, ELSEVIER INC, US, vol. 100, no. 12, 1 December 2006 (2006-12-01), pages 2150 - 2161, XP027900346, ISSN: 0162-0134, [retrieved on 20061201]
MICHAEL L. SCHILSKY: "Treatment of Wilson's disease: What are the relative roles of penicillamine, trientine, and zinc supplementation?", CURRENT GASTROENTEROLOGY REPORTS, vol. 3, no. 1, 1 February 2001 (2001-02-01), US, pages 54 - 59, XP055374650, ISSN: 1522-8037, DOI: 10.1007/s11894-001-0041-4
GRACE E. KENNEY ET AL: "Chemistry and Biology of the Copper Chelator Methanobactin", ACS CHEMICAL BIOLOGY, vol. 7, no. 2, 17 February 2012 (2012-02-17), US, pages 260 - 268, XP055307727, ISSN: 1554-8929, DOI: 10.1021/cb2003913
M.-L. PESCH ET AL: "Competitive ligand exchange between Cu-humic acid complexes and methanobactin", GEOBIOLOGY, vol. 11, no. 1, 22 January 2013 (2013-01-22), pages 44 - 54, XP055307717, ISSN: 1472-4677, DOI: 10.1111/gbi.12010
MARIE-LAURE PESCH ET AL: "Copper complexation of methanobactin isolated from Methylosinus trichosporium OB3b: pH-dependent speciation and modeling", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 116, 1 November 2012 (2012-11-01), US, pages 55 - 62, XP055307730, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2012.07.008
CHOI D W ET AL: "Spectral and thermodynamic properties of Ag(I), Au(III), Cd(II), Co(II), Fe(III), Hg(II), Mn(II), Ni(II), Pb(II), U(IV), and Zn(II) binding by methanobactin from Methylosinus trichosporium OB3b", JOURNAL OF INORGANIC BIOCHEMISTRY, ELSEVIER INC, US, vol. 100, no. 12, 1 December 2006 (2006-12-01), pages 2150 - 2161, XP027900346, ISSN: 0162-0134, [retrieved on 20061201]
MICHAEL L. SCHILSKY: "Treatment of Wilson's disease: What are the relative roles of penicillamine, trientine, and zinc supplementation?", CURRENT GASTROENTEROLOGY REPORTS, vol. 3, no. 1, 1 February 2001 (2001-02-01), US, pages 54 - 59, XP055374650, ISSN: 1522-8037, DOI: 10.1007/s11894-001-0041-4
Attorney, Agent or Firm:
WEINZIERL, Gerhard et al. (DE)
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