Title:
MEDICAL APPLICATION OF PYRIMIDINE SULFONAMIDES DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2020/062912
Kind Code:
A1
Abstract:
The invention provides a compound conforming to general formula (I) and the application of isomers or pharmacologically acceptable salts thereof in the preparation of a pharmaceutical composition for treating or preventing high altitude sickness. The altitude sickness is selected from acute and chronic altitude sicknesses occurred in an altitude environment with an altitude of 2,000m or above.
Inventors:
HE KUNLUN (CN)
GAO XIAOJIAN (CN)
LIU CHUNLEI (CN)
ZHANG ZEYU (CN)
LI XIN (CN)
LI CHEN (CN)
LUO YUNFU (CN)
LEI MAOYI (CN)
LI JUNMIAO (CN)
WANG YIWEI (CN)
GAO XIAOJIAN (CN)
LIU CHUNLEI (CN)
ZHANG ZEYU (CN)
LI XIN (CN)
LI CHEN (CN)
LUO YUNFU (CN)
LEI MAOYI (CN)
LI JUNMIAO (CN)
WANG YIWEI (CN)
Application Number:
PCT/CN2019/090109
Publication Date:
April 02, 2020
Filing Date:
June 05, 2019
Export Citation:
Assignee:
CHINESE PLA GENERAL HOSPITAL (CN)
SHIJIAZHUANG SAGACITY NEW DRUG DEV COMPANY LTD (CN)
SHIJIAZHUANG SAGACITY NEW DRUG DEV COMPANY LTD (CN)
International Classes:
C07D405/14; A61K31/506; A61P9/00; A61P9/12; A61P11/00; A61P39/00; C07D417/14; C07D471/04; C07D491/107
Domestic Patent References:
| WO2002053557A1 | 2002-07-11 |
Foreign References:
| CN109232546A | 2019-01-18 | |||
| CN1524079A | 2004-08-25 | |||
| CN1711248A | 2005-12-21 | |||
| CN103829245A | 2014-06-04 | |||
| CN103948896A | 2014-07-30 | |||
| CN104274808A | 2015-01-14 | |||
| CN104288262A | 2015-01-21 | |||
| CN104288735A | 2015-01-21 | |||
| CN104288476A | 2015-01-21 | |||
| CN104721202A | 2015-06-24 | |||
| CN104706771A | 2015-06-17 | |||
| CN105168308A | 2015-12-23 | |||
| CN105193839A | 2015-12-30 | |||
| CN102510719A | 2012-06-20 |
Other References:
NEUMANN, THOMAS; BAERTSCHI, MICHAEL; VILSER, WALTHARD; DRINDA, STEFAN; FRANZ, MARCUS; BRÜCKMANN, ANDREAS; WOLF, GUNTER; JUNG, CHRI: "Retinal Vessel Regulation at High Altitudes1", CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, vol. 63, no. 3, 12 September 2016 (2016-09-12), pages 281 - 292, XP009527212, ISSN: 1386-0291, DOI: 10.3233/CH-162041
BETGE, S. ET AL.: "Influence of Macitentan on the Vascular Tone and Recruitment of Capillaries under Hypobaric Hypoxia in High Altitude", EUROPEAN HEART JOURNAL, vol. 38, no. l, 29 August 2017 (2017-08-29), pages 279, XP055699691, ISSN: 1522-9645
MODESTI, P. A. ET AL.: "Role of Endothelin-1 in Exposure to High Altitude Acute Mountain Sickness and Endothelin-1 (ACME-1) Study", CIRCULATION, vol. 114, no. 13, 26 September 2006 (2006-09-26), pages 1410 - 1416, XP055699693, ISSN: 1524-4539, DOI: 10.1161/CIRCULATIONAHA.105.605527
See also references of EP 3851435A4
BETGE, S. ET AL.: "Influence of Macitentan on the Vascular Tone and Recruitment of Capillaries under Hypobaric Hypoxia in High Altitude", EUROPEAN HEART JOURNAL, vol. 38, no. l, 29 August 2017 (2017-08-29), pages 279, XP055699691, ISSN: 1522-9645
MODESTI, P. A. ET AL.: "Role of Endothelin-1 in Exposure to High Altitude Acute Mountain Sickness and Endothelin-1 (ACME-1) Study", CIRCULATION, vol. 114, no. 13, 26 September 2006 (2006-09-26), pages 1410 - 1416, XP055699693, ISSN: 1524-4539, DOI: 10.1161/CIRCULATIONAHA.105.605527
See also references of EP 3851435A4
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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