Title:
MEDICAL COMPOSITION CONTAINING NITROETHENEAMINE DERIVATIVE OR SALT THEREOF AS ACTIVE CONSTITUENT
Document Type and Number:
WIPO Patent Application WO/2000/016766
Kind Code:
A1
Abstract:
A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by formula (I) wherein R?1¿ is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic group, or a cyano group; R?2¿ and R?3¿ may be each a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic group, or -A-R?7¿ (wherein A is S, SO, SO¿2?, SO¿3?, CO or CO¿2?, and R?7¿ is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic group), or may form N=CR?8¿R?9¿ (wherein R?8¿ and R?9¿ are each a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic group, an alkoxy or aryloxy group, a cyano group, a nitro group, or -A-R?7¿); R?4¿ and R?5¿ may be each a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic group, an alkoxy group, an amino group, an aryloxy group, -A-R?7¿ , a cyano group, an ester group or a hydroxyl group, or may form N=CR?8¿R?9¿; R?6¿ is a hydrogen atom, a nitro group, a cyano group, -A-R?7¿, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heterocyclic group, an alkoxy group, an amino group, or a halogen atom; and further R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ may form a ring containing or not containing a heteroatom, or a salt thereof as an active constituent.
Inventors:
KATO FUMINORI (JP)
MIYATA KEIZO (JP)
KIMURA HIROHIKO (JP)
YAMAMOTO KAZUHIRO (JP)
IKEGAMI HIROYUKI (JP)
TAKEO HIROMI (JP)
MIYATA KEIZO (JP)
KIMURA HIROHIKO (JP)
YAMAMOTO KAZUHIRO (JP)
IKEGAMI HIROYUKI (JP)
TAKEO HIROMI (JP)
Application Number:
PCT/JP1999/005148
Publication Date:
March 30, 2000
Filing Date:
September 21, 1999
Export Citation:
Assignee:
ISHIHARA SANGYO KAISHA (JP)
KATO FUMINORI (JP)
MIYATA KEIZO (JP)
KIMURA HIROHIKO (JP)
YAMAMOTO KAZUHIRO (JP)
IKEGAMI HIROYUKI (JP)
TAKEO HIROMI (JP)
KATO FUMINORI (JP)
MIYATA KEIZO (JP)
KIMURA HIROHIKO (JP)
YAMAMOTO KAZUHIRO (JP)
IKEGAMI HIROYUKI (JP)
TAKEO HIROMI (JP)
International Classes:
A61K31/00; A61K31/428; C07C243/16; C07C243/20; C07C243/22; C07C243/28; C07C243/38; C07C251/76; C07C251/80; C07C251/86; C07C257/06; C07C281/02; C07C311/49; C07C311/51; C07C323/36; C07C327/58; C07D213/40; C07D213/53; C07D213/74; C07D213/77; C07D215/38; C07D231/38; C07D231/56; C07D233/52; C07D239/42; C07D239/52; C07D239/94; C07D241/44; C07D251/46; C07D263/58; C07D277/82; C07D295/125; C07D295/30; C07D307/40; C07D307/52; C07D307/88; C07D317/58; C07D317/66; C07D319/18; C07D333/20; C07D333/22; C07D401/12; C07D405/12; C07D471/04; C07D495/04; (IPC1-7): A61K31/135; A61K31/195; A61K31/22; A61K31/335; A61K31/36; A61K31/365; A61K31/38; A61K31/40; A61K31/415; A61K31/42; A61K31/425; A61K31/435; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/505; A61K31/535; C07C311/49; C07C323/27; C07C323/48; C07D213/38; C07D213/42; C07D213/76; C07D215/42; C07D231/38; C07D239/42; C07D251/46; C07D253/06; C07D263/58; C07D277/82; C07D295/12; C07D295/22; C07D317/58; C07D319/14; C07D333/22; C07D405/12; C07D407/12; C07D471/04; C07D495/04
Foreign References:
| US4098898A | 1978-07-04 |
Other References:
SORBA GIOVANNI ET AL.: "Potential histamine H2-receptor antagonists: ranitidine analogues containing (semicarbazono equivalent) groups", ARCH. PHARM.,, vol. 317, no. 6, 1984, pages 496 - 501, XP002925886
TOSHIMASA ISHIDA ET AL.: "On the Structure-Activity Relationship of Histamine H2-Receptor Antagonists Based on the X-Ray Crystal Structures and 1H-NMR Spectra of Amidine Derivatives", MOL. PHARMACOL.,, vol. 31, no. 4, 1987, pages 410 - 416, XP002925887
QUADRI LUISA ET AL.: "Synthesis Quantitative Structure-Activity Relationships of 17beta-(Hydrazonomethyl)-5beta-androstane-3beta,14beta-diol Derivatives That Bind to Na+,K+-ATPase Receptor", J. MED. CHEM.,, vol. 39, no. 17, 1996, pages 3385 - 3393, XP002925888
VALLI MATTHEW J. ET AL.: "Synthesis and Cholinergic Properties of N-aryl-2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethylamino Analogs of Ranitidine", J. MED. CHEM.,, vol. 35, no. 17, 1992, pages 3141 - 3147, XP002925889
SCHAEFER VON H. ET AL.: "Cyclizations with 1-nitro-2-anilinoethylenes", J. PRAKT. CHEM.,, vol. 319, no. 1, 1977, pages 149 - 158, XP002925890
See also references of EP 1116486A4
TOSHIMASA ISHIDA ET AL.: "On the Structure-Activity Relationship of Histamine H2-Receptor Antagonists Based on the X-Ray Crystal Structures and 1H-NMR Spectra of Amidine Derivatives", MOL. PHARMACOL.,, vol. 31, no. 4, 1987, pages 410 - 416, XP002925887
QUADRI LUISA ET AL.: "Synthesis Quantitative Structure-Activity Relationships of 17beta-(Hydrazonomethyl)-5beta-androstane-3beta,14beta-diol Derivatives That Bind to Na+,K+-ATPase Receptor", J. MED. CHEM.,, vol. 39, no. 17, 1996, pages 3385 - 3393, XP002925888
VALLI MATTHEW J. ET AL.: "Synthesis and Cholinergic Properties of N-aryl-2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethylamino Analogs of Ranitidine", J. MED. CHEM.,, vol. 35, no. 17, 1992, pages 3141 - 3147, XP002925889
SCHAEFER VON H. ET AL.: "Cyclizations with 1-nitro-2-anilinoethylenes", J. PRAKT. CHEM.,, vol. 319, no. 1, 1977, pages 149 - 158, XP002925890
See also references of EP 1116486A4
Attorney, Agent or Firm:
Ogawa, Toshiharu (Kanda-Higashimatsushitacho Chiyoda-ku Tokyo, JP)
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