Title:
MEDICAL HYDROGEL WITH RADIATION PREVENTION EFFECT
Document Type and Number:
WIPO Patent Application WO/2020/155554
Kind Code:
A1
Abstract:
Disclosed is a medical hydrogel formed by in-situ crosslinking of formyl-terminated star-shaped multi-arm polyethylene glycol and a poly-amino compound. The formyl groups are linked to star-shaped multi-arm polyethylene glycol by means of a chemical bond such as an ether bond, an amide bond, an ester bond, an ammonia ester bond, an imine bond or a urea bond. The molar ratio of amino groups in the poly-amino compound to the formyl groups in formyl-terminated star-shaped multi-arm polyethylene glycol is (0.4-4.4):1. The poly-amino compound is polylysine or a mixture of polylysine and polyethyleneimine, and the molar ratio of polylysine to polyethyleneimine is (2-30):3. The hydrogel is high in gel formation speed, has long-term stability in an aqueous solution, still maintains good swelling performance and high stability after being subjected to irradiation several time, and can be used as a medical radiotherapy protection pad for radiation protection.
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Inventors:
PAN ZHEN (CN)
CHEN LIANG (CN)
HOU SEN (CN)
CHEN LIANG (CN)
HOU SEN (CN)
Application Number:
PCT/CN2019/094653
Publication Date:
August 06, 2020
Filing Date:
July 04, 2019
Export Citation:
Assignee:
SHANGHAI RUINING BIOTECHNOLOGY COLTD (CN)
International Classes:
A61L31/06; A61K47/18; A61K47/34; A61L24/04; A61L31/14
Foreign References:
| CN109646723A | 2019-04-19 | |||
| CN105561404A | 2016-05-11 | |||
| CN105561404A | 2016-05-11 | |||
| CN102499810A | 2012-06-20 | |||
| CN107693838A | 2018-02-16 | |||
| CN105111512A | 2015-12-02 |
Attorney, Agent or Firm:
NANJING IPLEADER INTELLECTUAL PROPERTY AGENCY FIRM (CN)
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