Title:
MEDICAL IMAGING OF GLYCOGEN SYNTHASE KINASE-3 WITH A PET PROBE
Document Type and Number:
WIPO Patent Application WO/2023/091697
Kind Code:
A3
Abstract:
Disclosed are compounds of formula (1), formula (2), formula (75), formula (80) and formula (90): wherein R1, R2, R3, R4, and R5 can be selected from the group consisting of hydrogen, unsubstituted alkyl, substituted alkyl, unsubstituted haloalkyl, substituted haloalkyl, unsubstituted hydroxyalkyl, substituted hydroxyalkyl, benzyl, phenyl, substituted phenyl, unsubstituted alkenyl, substituted alkenyl, unsubstituted cycloalkyl, substituted cycloalkyl, hydroxy, unsubstituted alkoxy, substituted alkoxy, unsubstituted haloalkoxy, substituted haloalkoxy, unsubstituted phenoxy, substituted phenoxy, unsubstituted sulfonyloxy, substituted sulfonyloxy, carbonyl, carboxy, unsubstituted amino, substituted amino, unsubstituted amido, and substituted amido, and wherein at least one atom in R1 is replaced with a positron emitter. Also disclosed are methods for in vivo imaging of a subject using the compound of formula (1) or formula (2) or formula (75) or formula (80) or formula (90).
Inventors:
PANDEY MUKESH K (US)
LOWE VAL J (US)
BANSAL ADITYA (US)
STEIN HEATHER M (US)
GUNDAM SURENDRA REDDY (US)
LOWE VAL J (US)
BANSAL ADITYA (US)
STEIN HEATHER M (US)
GUNDAM SURENDRA REDDY (US)
Application Number:
PCT/US2022/050454
Publication Date:
July 06, 2023
Filing Date:
November 18, 2022
Export Citation:
Assignee:
MAYO FOUND MEDICAL EDUCATION & RES (US)
International Classes:
C07D213/81; A61K31/444; A61P35/00
Other References:
GAO MINGZHANG ET AL: "Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer's disease", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 27, no. 4, 16 January 2017 (2017-01-16), pages 740 - 743, XP029906450, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2017.01.041
ZHONG YUHUA ET AL: "Novel 18 F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3[beta]", MOLECULAR PHARMACEUTICS, vol. 18, no. 3, 25 January 2021 (2021-01-25), US, pages 1277 - 1284, XP093027947, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.0c01133
ZHONG YUHUA ET AL: "Novel 18 F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3[beta]", MOLECULAR PHARMACEUTICS, vol. 18, no. 3, 25 January 2021 (2021-01-25), US, pages 1277 - 1284, XP093027947, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.0c01133
Attorney, Agent or Firm:
ROCHE, Richard T. (US)
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