MEDICAL IMPLANT SURFACE-MODIFIED WITH FUNCTIONAL POLYPEPTIDE

Title:

MEDICAL IMPLANT SURFACE-MODIFIED WITH FUNCTIONAL POLYPEPTIDE

Document Type and Number:

WIPO Patent Application WO/2020/226250

Kind Code:

A1

Abstract:

Provided is a medical implant which comprises: an implant substrate having a surface made of a silicone material; linkers of which each has one end attached to the surface of the implant substrate; and cytokines coupled to the other ends of the linkers, and which induces the secretion of anti-inflammatory cytokines, thereby enabling the reduction of a capsular contracture, which is one of the complications that can occur after breast implant transplant surgery in patients.

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Inventors:

HEO CHAN YEONG (KR)
NAM SUN YOUNG (KR)
LEE MI JI (KR)
SHIN BYUNG HO (KR)
SHIN DONG SIK (KR)
KIM SEONG SOO (KR)

Application Number:

PCT/KR2019/017471

Publication Date:

November 12, 2020

Filing Date:

December 11, 2019

Export Citation:

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Assignee:

SEOUL NAT UNIV HOSPITAL (KR)
UNIV SOOKMYUNG WOMENS IND ACAD COOP FOUND (KR)

International Classes:

A61F2/12; A61F2/00; A61L27/22; A61L27/34; A61L27/54

Domestic Patent References:

WO1994001483A1	1994-01-20
WO2011066580A1	2011-06-03

Foreign References:

JP2018504167A	2018-02-15
JP2017043547A	2017-03-02

Other References:

CHO.H.: "Development and Characterization of Functional PDMS Modified with Itaconic Acid for Implantable Medical Instrument and Tissue Engineering", MASTER'S THESIS, MAJOR IN BIO ENGINEERING, DEPARTMENT OF INTEGRATIVE ENGINEERING. THE GRADUATE SCHOOL CHUNG-ANG UNIVERSITY, vol. i-viii, August 2017 (2017-08-01), pages 1 - 59
NAM, S. -Y. ET AL.: "Sequence delivery of interleukin-4 to facilitate the M1-to-M2 transition of macrophages and inhibit the formation of fibrous capsules around silicone implants", RESEARCH FAIR (2018 HEALTHCARE INNOVATION PARK RESEARCH FAIR), 11 December 2018 (2018-12-11)

Attorney, Agent or Firm:

Y.P.LEE, MOCK & PARTNERS (KR)

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