Title:
MEDICAL USE OF UBV.E4B PROTEIN, AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/231402
Kind Code:
A1
Abstract:
Provided is use of UbV.E4B protein in the preparation of a medicament for promoting central nervous regeneration. The UbV.E4B protein promotes the axonal regeneration of a central nervous system by selectively inhibiting a Ube4b ubiquitination factor. The recombinant UbV.E4B protein used alone can promote the central nervous axonal regeneration. The Ube4b ubiquitination factor promotes the central nervous axonal regeneration by regulating and controlling mTOR and p53 dual molecular signal paths. The knock-down or blockage of PTEN or MDM2 genes has a synergistic effect with the knock-down or blockage of Ube4b, which is more beneficial to the nervous axonal regeneration. Provided is use of the Ube4b ubiquitination factor as a screening target in screening a medicament for promoting the axonal regeneration of the central nervous system. Further provided is a pharmaceutical composition for promoting the central nervous axonal regeneration.
Inventors:
WANG XUHUA (CN)
Application Number:
PCT/CN2022/142349
Publication Date:
December 07, 2023
Filing Date:
December 27, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61K38/45; A61P25/00; G01N33/53
Domestic Patent References:
| WO2016134246A2 | 2016-08-25 |
Other References:
JIN SHUANG, XIANGFENG CHEN, HANYU ZHENG, WANXIONG CAI, XURONG LIN, XIANGXING KONG, YINGCHUN NI, JINGJIA YE, XIAODAN LI, LUOAN SHEN: "Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke", ISCIENCE, CELL PRESS, US, vol. 26, no. 7, 1 July 2023 (2023-07-01), US , XP093116986, ISSN: 2589-0042, DOI: 10.1016/j.isci
GABRIELSEN MADS; BUETOW LORI; NAKASONE MARK A.; AHMED SYED FEROJ; SIBBET GARY J.; SMITH BRIAN O.; ZHANG WEI; SIDHU SACHDEV S.; HUA: "A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants", MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, vol. 68, no. 2, 2017, AMSTERDAM, NL, pages 456 - 470, XP085234123, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.09.027
GABRIELSEN MADS; BUETOW LORI; NAKASONE MARK A.; AHMED SYED FEROJ; SIBBET GARY J.; SMITH BRIAN O.; ZHANG WEI; SIDHU SACHDEV S.; HUA: "A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants", MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, vol. 68, no. 2, 2017, AMSTERDAM, NL, pages 456 - 470, XP085234123, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.09.027
Attorney, Agent or Firm:
FIWIS INTELLECTUAL PROPERTY LAW FIRM (CN)
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