Title:
MEDICAL USE
Document Type and Number:
WIPO Patent Application WO/2013/064830
Kind Code:
A3
Abstract:
The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynaecological condition in which an activity of AR and/or ER is a contributory factor in a subject. Preferably, the molecule comprises or consists of the structure: Bj[(Pro)n-Xr-His-Pro-His-Ala-Arg-lle-Lys]m-Rp, or Bj[lys-ile-arg-ala-his-pro-his-xr-(pro)n]m-Rp, or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-xr-(pro)n] is the retro-inverso peptide of [(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys].
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Inventors:
ECCLESTON MARK (GB)
VAINIKKA SATU (GB)
MORRIS GEORGE STEVEN (GB)
VAINIKKA SATU (GB)
MORRIS GEORGE STEVEN (GB)
Application Number:
PCT/GB2012/052722
Publication Date:
August 22, 2013
Filing Date:
November 01, 2012
Export Citation:
Assignee:
VALIRX PLC (GB)
International Classes:
A61K38/00; A61P35/00; A61K38/08; A61K39/395; A61P5/26; C07K5/097; C07K5/117; C07K7/06; C07K7/08; C07K14/72; C07K16/28; G01N33/68
Domestic Patent References:
| WO2008113770A2 | 2008-09-25 | |||
| WO2000001813A2 | 2000-01-13 | |||
| WO2009132307A1 | 2009-10-29 |
Other References:
A MIGLIACCIO ET AL: "Inhibition of the SH3 domain-mediated binding of Src to the androgen receptor and its effect on tumor growth", ONCOGENE, vol. 26, no. 46, 11 October 2007 (2007-10-11), pages 6619 - 6629, XP055066805, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1210487
Attorney, Agent or Firm:
DIDMON, Mark (The Belgrave CentreTalbot Street,Nottingham, Nottinghamshire NG1 5GG, GB)
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