Title:
MEDICAL UTILITY OF GLYCAN-BINDING PROTEINS AND GLYCANS
Document Type and Number:
WIPO Patent Application WO/2011/047794
Kind Code:
A3
Abstract:
The present invention relates to the use of glycan-binding polypeptides and glycans as a medicament, in particular for treating and/or preventing helminthic infections or an immune disease. Moreover, the present invention is directed to corresponding pharmaceutical compositions, food products and animal feed comprising isolated glycans and/or glycan-binding polypeptides. In addition, the present invention teaches methods for identifying anti-helminthic carbohydrate-binding polypeptides, for identifying helminthic glycan and gene targets involved in glycan-mediated toxicity, for identifying helminths susceptible to glycan-mediated toxicity, and for identifying anti-helminthic and anti-allergic substances.
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Inventors:
KUNZLER MARKUS (CH)
WAELTI MARTIN (CH)
BUTSCHI ALEX (CH)
AEBI MARKUS (CH)
HENGARTNER MICHAEL (CH)
WAELTI MARTIN (CH)
BUTSCHI ALEX (CH)
AEBI MARKUS (CH)
HENGARTNER MICHAEL (CH)
Application Number:
PCT/EP2010/006228
Publication Date:
October 13, 2011
Filing Date:
October 12, 2010
Export Citation:
Assignee:
ETH ZUERICH (CH)
UNIV ZUERICH (CH)
KUNZLER MARKUS (CH)
WAELTI MARTIN (CH)
BUTSCHI ALEX (CH)
AEBI MARKUS (CH)
HENGARTNER MICHAEL (CH)
UNIV ZUERICH (CH)
KUNZLER MARKUS (CH)
WAELTI MARTIN (CH)
BUTSCHI ALEX (CH)
AEBI MARKUS (CH)
HENGARTNER MICHAEL (CH)
International Classes:
A23K1/16; A61K38/16; A61K31/00; A61K38/17; A61K39/00; A61K39/395; C07K16/44; G01N33/50; G01N33/53
Domestic Patent References:
| WO2008142483A2 | 2008-11-27 | |||
| WO2007085057A1 | 2007-08-02 | |||
| WO2005065017A2 | 2005-07-21 | |||
| WO2005092368A1 | 2005-10-06 | |||
| WO1989009601A2 | 1989-10-19 |
Foreign References:
| EP1557172A1 | 2005-07-27 | |||
| US20060009378A1 | 2006-01-12 |
Other References:
GRIFFITTS JOEL S ET AL: "Glycolipids as receptors for Bacillus thuringiensis crystal toxin", SCIENCE (WASHINGTON D C), vol. 307, no. 5711, 11 February 2005 (2005-02-11), pages 922 - 925, XP002629519, ISSN: 0036-8075
KOHATSU LUCIANA ET AL: "Galectin-3 induces death of Candida species expressing specific beta-1,2-linked Mannans", JOURNAL OF IMMUNOLOGY, vol. 177, no. 7, October 2006 (2006-10-01), pages 4718 - 4726, XP002629520, ISSN: 0022-1767
ANNA R YOUNG ET AL: "Galectins in parasite infection and allergic inflammation", GLYCOCONJUGATE JOURNAL, KLUWER ACADEMIC PUBLISHERS, BO, vol. 19, no. 7-9, 1 January 2002 (2002-01-01), pages 601 - 606, XP019206950, ISSN: 1573-4986, DOI: DOI:10.1023/B:GLYC.0000014091.00844.0A
BUTSCHI ALEX ET AL: "Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.", PLOS PATHOGENS JAN 2010 LNKD- PUBMED:20062796, vol. 6, no. 1, E1000717, January 2010 (2010-01-01), pages 1 - 15, XP002629521, ISSN: 1553-7374
WEI J-Z ET AL: "BACILLUS THURINGIENSIS CRYSTAL PROTEINS THAT TARGET NEMATODES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US, vol. 100, no. 5, 4 March 2003 (2003-03-04), pages 2760 - 2765, XP009084270, ISSN: 0027-8424, DOI: DOI:10.1073/PNAS.0538072100
KOHATSU LUCIANA ET AL: "Galectin-3 induces death of Candida species expressing specific beta-1,2-linked Mannans", JOURNAL OF IMMUNOLOGY, vol. 177, no. 7, October 2006 (2006-10-01), pages 4718 - 4726, XP002629520, ISSN: 0022-1767
ANNA R YOUNG ET AL: "Galectins in parasite infection and allergic inflammation", GLYCOCONJUGATE JOURNAL, KLUWER ACADEMIC PUBLISHERS, BO, vol. 19, no. 7-9, 1 January 2002 (2002-01-01), pages 601 - 606, XP019206950, ISSN: 1573-4986, DOI: DOI:10.1023/B:GLYC.0000014091.00844.0A
BUTSCHI ALEX ET AL: "Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.", PLOS PATHOGENS JAN 2010 LNKD- PUBMED:20062796, vol. 6, no. 1, E1000717, January 2010 (2010-01-01), pages 1 - 15, XP002629521, ISSN: 1553-7374
WEI J-Z ET AL: "BACILLUS THURINGIENSIS CRYSTAL PROTEINS THAT TARGET NEMATODES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US, vol. 100, no. 5, 4 March 2003 (2003-03-04), pages 2760 - 2765, XP009084270, ISSN: 0027-8424, DOI: DOI:10.1073/PNAS.0538072100
Attorney, Agent or Firm:
KASCHE, André (Resirain 1, Zollikerberg, CH)
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