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Title:
MEDICAMENT EXCIPIENT PARTICLES FOR TISSUE-SPECIFIC APPLICATION OF A MEDICAMENT
Document Type and Number:
WIPO Patent Application WO1999020256
Kind Code:
A3
Abstract:
The invention relates to medicament excipient particles which are suitable for tissue-specific application of a medicament, especially to the central nervous system (CNS). The inventive particles can be loaded with or be free of the active substance. At least one detection protein is bonded to the particle surface or alternatively, the particle surface is modified in such a way that a detection protein bonds with it on contact.

Inventors:
MUELLER RAINER H (DE)
LUECK MARTIN (DE)
KREUTER JOERG (DE)
Application Number:
PCT/EP1998/006429
Publication Date:
August 19, 1999
Filing Date:
October 13, 1998
Export Citation:
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Assignee:
DDS DRUG DELIVERY SERVICE GES (DE)
MUELLER RAINER H (DE)
LUECK MARTIN (DE)
KREUTER JOERG (DE)
International Classes:
A61K9/127; A61K9/50; A61K9/51; B01D39/20; A61K47/48; B01D29/11; B01J8/00; B01J8/22; C07B61/00; C07C1/04; C07C7/144; C07C9/02; C10G2/00; (IPC1-7): A61K9/16; A61K9/51; A61K9/00
Domestic Patent References:
WO1995026376A21995-10-05
WO1995000126A11995-01-05
WO1993000076A11993-01-07
Foreign References:
DE4310935A11993-11-18
DE19745950A11999-04-22
Other References:
BLUNK T ET AL.: "Kinetics of plasma protein adsorption on model particles for controlled drug delivery and drug targeting", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 42, no. 4, 1996, pages 262 - 268, XP002102920
MÜLLER R H ET AL.: "Intravenously injected particles. Surface properties and interaction with blood proteins - the key determining the organ distribution. In: Scientific and Clinical Applications of Magnetic Carriers", 1997, PLENUM PRESS, NEW YORK, XP002102925
ALYAUTDIN R N ET AL.: "Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles", PHARMACEUTICAL RESEARCH, vol. 14, no. 3, 1997, pages 325 - 328, XP002102921
TRÖSTER S D ET AL.: "Modification of the body distribution of poly(methyl methacrylate) nanoparticles in rats by coating with surfactants", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 61, 1990, pages 85 - 100, XP002102922
ALYAUTDIN R ET AL: "ANALGESIC ACTIVITY OF THE HEXAPEPTIDE DALARGIN ADSORBED ON THE SURFACE OF POLYSORBATE 80-COATED POLY(BUTYL CYANOACRYLATE) NANOPARTICLES", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 41, no. 1, 1 January 1995 (1995-01-01), pages 44 - 48, XP000482891
MÜLLER R H ET AL.: "Solid lipid nanoparticles (SLN) as potential carrier for human use: interaction with human granulocytes", JOURNAL OF CONTROLLED RELEASE, vol. 47, 1997, pages 261 - 269, XP002102923
KREUTER J: "NANOPARTICLE-BASED DRUG DELIVERY SYSTEMS", JOURNAL OF CONTROLLED RELEASE, vol. 16, no. 1 / 02, 1 June 1991 (1991-06-01), pages 169 - 176, XP000219660
LÜCK M ET AL.: "Plasma protein adsorption on biodegradable microspheres consisting of poly(D,L-lactide-co-glycolide), poly(L-lactide) or ABA triblock copolymers containing poly(oxyethylene). Influence of production method and polymer composition", JOURNAL OF CONTROLLED RELEASE, vol. 55, 1998, pages 107 - 120, XP002102924
KREUTER J ET AL: "INFLUENCE OF THE TYPE OF SURFACTANT ON THE ANALGESIC EFFECTS INDUCED BY THE PEPTIDE DALARGIN AFTER ITS DELIVERY ACROSS THE BLOOD-BRAIN BARRIER USING SURFACTANT-COATED NANOPARTICLES", JOURNAL OF CONTROLLED RELEASE, vol. 49, no. 1, 10 November 1997 (1997-11-10), pages 81 - 87, XP000667154
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