Title:
MEDICAMENT HAVING ANTI-INFLAMMATORY BOWEL DISEASE FUNCTION, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/024078
Kind Code:
A1
Abstract:
The present application provides a medicament having an anti-inflammatory bowel disease function, and a preparation method therefor and an application thereof. The medicament has a structure as represented in formula I or formula II. The medicament and a pharmaceutically acceptable salt, a solvate, a prodrug, a tautomer, a stereoisomer, or a pharmaceutical composition thereof provided by the present application have a good effect on inflammatory bowel diseases, can be used for preparing medicaments for treating the inflammatory bowel diseases, and have important clinical significance and wide application prospects.
Inventors:
DENG SHIPING (CN)
CAO YU (CN)
LI ZHI (CN)
YU YUNHUI (CN)
ZHANG KUI (CN)
ZHANG MINJIE (CN)
YUAN GAOGANG (CN)
XU TAO (CN)
YU GANG (CN)
JIANG CHUANLIANG (CN)
CAO YU (CN)
LI ZHI (CN)
YU YUNHUI (CN)
ZHANG KUI (CN)
ZHANG MINJIE (CN)
YUAN GAOGANG (CN)
XU TAO (CN)
YU GANG (CN)
JIANG CHUANLIANG (CN)
Application Number:
PCT/CN2018/097685
Publication Date:
February 06, 2020
Filing Date:
July 28, 2018
Export Citation:
Assignee:
SUZHOU PHARMAVAN CO LTD (CN)
International Classes:
A61K31/09; A61K31/122; A61K31/222; A61K31/255; A61P1/00; A61P29/00; C07C41/00; C07C43/23; C07C45/29; C07C49/517; C07C67/03; C07C69/712
Foreign References:
| CN105198714A | 2015-12-30 | |||
| CN1646473A | 2005-07-27 | |||
| CN102552243A | 2012-07-11 | |||
| CN105198714A | 2015-12-30 | |||
| US8940945B2 | 2015-01-27 |
Other References:
YOSHIMURA, MORIO: "Diarylheptanoid sulfates and related compounds from Myrica rubra bark", JOURNAL OF NATURAL PRODUCTS, vol. 75, no. 10, 15 October 2012 (2012-10-15), pages 1798 - 1802, XP055684560, ISSN: 0163-3864, DOI: 10.1021/np300212c
WHITING, DONALD A: "Cyclization of 1, 7-diarylheptanoids through oxida- tive, reductive, and photochemical radical processes: total synthesis of the m, m-bridged biaryls myricanone and (± )-myricanol, and a related diar- yl ether", TETRAHEDRON LETTERS, vol. 19, no. 26, 31 December 1978 (1978-12-31), pages 2335 - 2338, XP055684565, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)95091-3
WHITING, DONALD A: "Total syntheses of the meta, meta-bridged biphenyls (±)-myricanol and myricanone, and of an isomeric biphenyl ether, a 14- oxa[7, l]metaparacyclophane", JOURNAL OF THE CHEMICAL SOCIETY, 1 January 1980 (1980-01-01), pages 623 - 628, XP055684566, ISSN: 0300-922X, DOI: 10.1039/P19800000623
IBRAHIM, SABRIN R. M: "Alnuheptanoid B: a new cyclic diarylheptanoid from Alnus japonica stem bark", RECORDS OF NATURAL PRODUCTS, vol. 10, no. 3, 1 January 2016 (2016-01-01), pages 362 - 368, XP055684570, ISSN: 1307-6167
KO, HA NA: "Anti-Inflammatory Constituents from the Branches of Pour- thiaea villosa (Thunb.) Decne", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 38, no. 7, 1 July 2017 (2017-07-01), pages 711 - 715, XP055684571, ISSN: 1229-5949, DOI: 10.1002/bkcs.11158
WHITING, DONALD A: "Cyclization of 1, 7-diarylheptanoids through oxida- tive, reductive, and photochemical radical processes: total synthesis of the m, m-bridged biaryls myricanone and (± )-myricanol, and a related diar- yl ether", TETRAHEDRON LETTERS, vol. 19, no. 26, 31 December 1978 (1978-12-31), pages 2335 - 2338, XP055684565, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)95091-3
WHITING, DONALD A: "Total syntheses of the meta, meta-bridged biphenyls (±)-myricanol and myricanone, and of an isomeric biphenyl ether, a 14- oxa[7, l]metaparacyclophane", JOURNAL OF THE CHEMICAL SOCIETY, 1 January 1980 (1980-01-01), pages 623 - 628, XP055684566, ISSN: 0300-922X, DOI: 10.1039/P19800000623
IBRAHIM, SABRIN R. M: "Alnuheptanoid B: a new cyclic diarylheptanoid from Alnus japonica stem bark", RECORDS OF NATURAL PRODUCTS, vol. 10, no. 3, 1 January 2016 (2016-01-01), pages 362 - 368, XP055684570, ISSN: 1307-6167
KO, HA NA: "Anti-Inflammatory Constituents from the Branches of Pour- thiaea villosa (Thunb.) Decne", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 38, no. 7, 1 July 2017 (2017-07-01), pages 711 - 715, XP055684571, ISSN: 1229-5949, DOI: 10.1002/bkcs.11158
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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