Title:
MEDICAMENTS FOR USE IN METHODS OF TREATING CANCERS WHICH COMPRISE A DECREASED AMOUNT OF HK36ME
Document Type and Number:
WIPO Patent Application WO/2014/188201
Kind Code:
A3
Abstract:
The invention relates to methods of treating cancers which comprise a decreased amount of H3K36me3. Kits for use in such methods are also provided.
Inventors:
PFISTER SOPHIA XIAO ZHANG (GB)
HUMPHREY TIMOTHY C (GB)
DEEGAN RACHEL S (GB)
HUMPHREY TIMOTHY C (GB)
DEEGAN RACHEL S (GB)
Application Number:
PCT/GB2014/051577
Publication Date:
March 05, 2015
Filing Date:
May 22, 2014
Export Citation:
Assignee:
CANCER REC TECH LTD (GB)
International Classes:
A61K48/00; A61K31/497; A61P35/00; C12N15/113
Domestic Patent References:
| WO2012074754A1 | 2012-06-07 | |||
| WO2011038160A2 | 2011-03-31 | |||
| WO2006005462A2 | 2006-01-19 |
Foreign References:
| US20120029062A1 | 2012-02-02 |
Other References:
LAURA CARRASSA ET AL: "Combined inhibition of Chk1 and Wee1: In vitro synergistic effect translates to tumor growth inhibition in vivo", CELL CYCLE, vol. 11, no. 13, 1 July 2012 (2012-07-01), pages 2507 - 2517, XP055140308, ISSN: 1538-4101, DOI: 10.4161/cc.20899
JENNY M. KREAHLING ET AL: "Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas", PLOS ONE, vol. 8, no. 3, 8 March 2013 (2013-03-08), pages e57523, XP055140781, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0057523
THAI HUU HO ET AL: "Regulation of SETD2, a histone methyltransferase, in advanced clear cell renal cell carcinoma (ccRCC)", J CLIN ONCOL 30, 2012 (SUPPL 5; ABSTR 368), 1 February 2012 (2012-02-01), XP055140427, Retrieved from the Internet [retrieved on 20140916]
SCHMIDT CHRISTINE K ET AL: "On Your MARK, Get SET(D2), Go! H3K36me3 Primes DNA Mismatch Repair", CELL, CELL PRESS, US, vol. 153, no. 3, 17 April 2013 (2013-04-17), pages 513 - 515, XP028589821, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2013.04.018
LI FENG ET AL: "The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutS[alpha]", CELL, CELL PRESS, US, vol. 153, no. 3, 25 April 2013 (2013-04-25), pages 590 - 600, XP028589806, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2013.03.025
G. DUNS ET AL: "Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma", CANCER RESEARCH, vol. 70, no. 11, 25 May 2010 (2010-05-25), pages 4287 - 4291, XP055140431, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-10-0120
ADAM M. FONTEBASSO ET AL: "Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas", ACTA NEUROPATHOLOGICA, vol. 125, no. 5, 16 February 2013 (2013-02-16), pages 659 - 669, XP055134406, ISSN: 0001-6322, DOI: 10.1007/s00401-013-1095-8
JENNY M. KREAHLING ET AL: "Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas", PLOS ONE, vol. 8, no. 3, 8 March 2013 (2013-03-08), pages e57523, XP055140781, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0057523
THAI HUU HO ET AL: "Regulation of SETD2, a histone methyltransferase, in advanced clear cell renal cell carcinoma (ccRCC)", J CLIN ONCOL 30, 2012 (SUPPL 5; ABSTR 368), 1 February 2012 (2012-02-01), XP055140427, Retrieved from the Internet
SCHMIDT CHRISTINE K ET AL: "On Your MARK, Get SET(D2), Go! H3K36me3 Primes DNA Mismatch Repair", CELL, CELL PRESS, US, vol. 153, no. 3, 17 April 2013 (2013-04-17), pages 513 - 515, XP028589821, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2013.04.018
LI FENG ET AL: "The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutS[alpha]", CELL, CELL PRESS, US, vol. 153, no. 3, 25 April 2013 (2013-04-25), pages 590 - 600, XP028589806, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2013.03.025
G. DUNS ET AL: "Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma", CANCER RESEARCH, vol. 70, no. 11, 25 May 2010 (2010-05-25), pages 4287 - 4291, XP055140431, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-10-0120
ADAM M. FONTEBASSO ET AL: "Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas", ACTA NEUROPATHOLOGICA, vol. 125, no. 5, 16 February 2013 (2013-02-16), pages 659 - 669, XP055134406, ISSN: 0001-6322, DOI: 10.1007/s00401-013-1095-8
Attorney, Agent or Firm:
CHAPMAN, Lee, Phillip (Gray's InnLondon, Greater London WC1R 5JJ, GB)
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