Title:
MEDICINAL AGENT CONTAINING PYRMIDOBENZOTHIAZIN-6-IMINE DERIVATIVE OR SALT THEREOF FOR PREVENTION AND/OR TREATMENT OF VIRAL INFECTION
Document Type and Number:
WIPO Patent Application WO/2012/153768
Kind Code:
A1
Abstract:
The problem addressed by the present invention is to provide a novel medicinal agent for the prevention and/or treatment of a viral infection. The present invention provides a medicinal agent for the prevention and/or treatment of a viral infection other than hepatitis C, and contains as the active ingredient the compound represented by general formula (I) or a salt thereof [In the formula, X represents a nitrogen atom or C‑R4; R1, R2, R3, and R4 each independently represent a hydrogen atom, C1
‑
6 alkyl group, C2
‑
6 alkenyl group, C2
‑
6 alkynyl group, C1
‑
6 alkoxy group, halogen atom, nitro group, amino group, C1
‑
3 mono- or di-alkyl amino group, C1
‑
3 alkyl carbonylamino group optionally substituted by a phenyl group, benzoyl amino group, trifluoromethyl group, azido group, carboxyl group, C1
‑
3 alkyl carbonyl group, C1
‑
3 alkoxy carbonyl group, carbamoyl group, naphthyl group, optionally substituted heteroaryl group, styryl group, C1
‑
3 alkyl thio group, C1
‑
6 hydroxyalkyl group, or a group having the structure represented by general formula (1) in the description; R2 and R3, or R3 and R4 are optionally crosslinked; R5 represents an optionally substituted C1
‑
5 straight chain alkylene group, with substituents on the alkylene group optionally bonded together to form a ring structure].
Inventors:
MAEDA HIDEKI (JP)
KATO TAKAYUKI (JP)
MATSUOKA MASAO (JP)
SHIMURA KAZUYA (JP)
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
MIZUHARA TSUKASA (JP)
KATO TAKAYUKI (JP)
MATSUOKA MASAO (JP)
SHIMURA KAZUYA (JP)
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
MIZUHARA TSUKASA (JP)
Application Number:
PCT/JP2012/061890
Publication Date:
November 15, 2012
Filing Date:
May 09, 2012
Export Citation:
Assignee:
FUJIFILM CORP (JP)
UNIV KYOTO (JP)
MAEDA HIDEKI (JP)
KATO TAKAYUKI (JP)
MATSUOKA MASAO (JP)
SHIMURA KAZUYA (JP)
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
MIZUHARA TSUKASA (JP)
UNIV KYOTO (JP)
MAEDA HIDEKI (JP)
KATO TAKAYUKI (JP)
MATSUOKA MASAO (JP)
SHIMURA KAZUYA (JP)
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
MIZUHARA TSUKASA (JP)
International Classes:
C07D513/04; A61K31/542; A61K31/547; A61P31/12; C07D513/10; C07D513/14; C07D513/20
Foreign References:
| DE2811131A1 | 1979-09-20 |
Other References:
CHOCKALINGAM,K. ET AL.: "A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107, no. 8, 2010, pages 3764 - 3769
HELLE,F. ET AL.: "Cyanovirin-N Inhibits Hepatitis C Virus Entry by Binding to Envelope Protein Glycans", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 35, 2006, pages 25177 - 25183
TIWARI,V. ET AL.: "A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion", ANTIVIRAL RESEARCH, vol. 84, no. 1, 2009, pages 67 - 75
BORISKIN,Y.S. ET AL.: "Arbidol: a broad-spectrum antiviral compound that blocks viral fusion", CURRENT MEDICINAL CHEMISTRY, vol. 15, no. 10, 2008, pages 997 - 1005
CHAN,E. ET AL.: "Development of a Moloney murine leukemia virus-based pseudotype anti-HIV assay suitable for accurate and rapid evaluation of HIV entry inhibitors", JOURNAL OF BIOMOLECULAR SCREENING, vol. 11, no. 6, 2006, pages 652 - 663
CHAMAOUN, A.M. ET AL.: "PD 404,182 Is a Virocidal Small Molecule That Disrupts Hepatitis C Virus and Human Immunodeficiency Virus", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 56, no. 2, February 2012 (2012-02-01), pages 672 - 681
HELLE,F. ET AL.: "Cyanovirin-N Inhibits Hepatitis C Virus Entry by Binding to Envelope Protein Glycans", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 35, 2006, pages 25177 - 25183
TIWARI,V. ET AL.: "A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion", ANTIVIRAL RESEARCH, vol. 84, no. 1, 2009, pages 67 - 75
BORISKIN,Y.S. ET AL.: "Arbidol: a broad-spectrum antiviral compound that blocks viral fusion", CURRENT MEDICINAL CHEMISTRY, vol. 15, no. 10, 2008, pages 997 - 1005
CHAN,E. ET AL.: "Development of a Moloney murine leukemia virus-based pseudotype anti-HIV assay suitable for accurate and rapid evaluation of HIV entry inhibitors", JOURNAL OF BIOMOLECULAR SCREENING, vol. 11, no. 6, 2006, pages 652 - 663
CHAMAOUN, A.M. ET AL.: "PD 404,182 Is a Virocidal Small Molecule That Disrupts Hepatitis C Virus and Human Immunodeficiency Virus", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 56, no. 2, February 2012 (2012-02-01), pages 672 - 681
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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