Title:
MEDICINAL AGENT FOR EVADING IMMUNE RESPONSE
Document Type and Number:
WIPO Patent Application WO/2013/024710
Kind Code:
A1
Abstract:
It is found that the immunostimulatory activity of nano particles on myeloid dendritic cells can be decreased and the phagocytosis of the nano particles by macrophages can also be decreased when the surfaces of the nano particles are modified with a RolA protein. The present invention provides nano particles each modified with a biological molecule having an immune-response-evading function.
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Inventors:
ABE KEIETSU (JP)
KAWAKAMI KAZUYOSHI (JP)
AJIRI TADAFUMI (JP)
FUKUMOTO MANABU (JP)
TAKAMI SEIICHI (JP)
TOGASHI TAKANARI (JP)
MURAGAKI KIMIHIDE (JP)
TAKAHASHI TORU (JP)
KAWAKAMI KAZUYOSHI (JP)
AJIRI TADAFUMI (JP)
FUKUMOTO MANABU (JP)
TAKAMI SEIICHI (JP)
TOGASHI TAKANARI (JP)
MURAGAKI KIMIHIDE (JP)
TAKAHASHI TORU (JP)
Application Number:
PCT/JP2012/069800
Publication Date:
February 21, 2013
Filing Date:
August 03, 2012
Export Citation:
Assignee:
UNIV TOHOKU (JP)
ABE KEIETSU (JP)
KAWAKAMI KAZUYOSHI (JP)
AJIRI TADAFUMI (JP)
FUKUMOTO MANABU (JP)
TAKAMI SEIICHI (JP)
TOGASHI TAKANARI (JP)
MURAGAKI KIMIHIDE (JP)
TAKAHASHI TORU (JP)
ABE KEIETSU (JP)
KAWAKAMI KAZUYOSHI (JP)
AJIRI TADAFUMI (JP)
FUKUMOTO MANABU (JP)
TAKAMI SEIICHI (JP)
TOGASHI TAKANARI (JP)
MURAGAKI KIMIHIDE (JP)
TAKAHASHI TORU (JP)
International Classes:
A61K47/02; A61K9/14; A61K47/42; B22F1/054; B22F1/102; B82Y5/00; C01G49/08; C12N15/00
Foreign References:
| JP2008260724A | 2008-10-30 | |||
| JP2012111694A | 2012-06-14 |
Other References:
AIMANIANDA,V. ET AL.: "Surface hydrophobin prevents immune recognition of airborne fungal spores", NATURE, vol. 460, no. 7259, 2009, pages 1117 - 21
ASUKA KASE ET AL.: "Kojikin no Saibo Hyoso Tanpakushitsu Hydrophobin(HypA) no Tanryotai Seisan", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2009, 2009, pages 272
JUN'YA ISHIKAWA ET AL.: "Kojikin Aspergillus oryzae no Saibo Hyoso Tanpakushitsu Hydrophobin-gun no Kyokuzai Kaiseki", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2009, 2009, pages 272
DAGENAIS,T.R. ET AL.: "Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer", INFECTION AND IMMUNITY, vol. 78, no. 2, 2010, pages 823 - 9
ASUKA KASE ET AL.: "Kojikin no Saibo Hyoso Tanpakushitsu Hydrophobin(HypA) no Tanryotai Seisan", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2009, 2009, pages 272
JUN'YA ISHIKAWA ET AL.: "Kojikin Aspergillus oryzae no Saibo Hyoso Tanpakushitsu Hydrophobin-gun no Kyokuzai Kaiseki", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2009, 2009, pages 272
DAGENAIS,T.R. ET AL.: "Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer", INFECTION AND IMMUNITY, vol. 78, no. 2, 2010, pages 823 - 9
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Patent business corporation cent Crest international patent firm (JP)
Patent business corporation cent Crest international patent firm (JP)
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