Title:
MEDICINAL AGENT AND BEVERAGE/FOOD FOR PREVENTING CEREBRAL DYSFUNCTION AND IMPROVING SAME
Document Type and Number:
WIPO Patent Application WO/2011/132435
Kind Code:
A1
Abstract:
Disclosed is a means for improving the symptoms of a cerebral dysfunction. The present inventors made a new discovery that the activity of brain aromatic monoamines increases when sepiapterin is administered peripherally. Disclosed, therefore, is a medicinal agent, which contains at least sepiapterin or a salt thereof, for preventing or improving cerebral dysfunction. Also disclosed is a beverage/food, which contains at least sepiapterin or a salt thereof, for preventing or improving cerebral dysfunction. Unlike tetrahydrobiopterin and the like, sepiapterin can control reductions in the brain neuron levels of brain aromatic monoamines (serotonin, dopamine, noradrenaline, and the like) and increase the activity thereof even when administered peripherally. Therefore, sepiapterin may be effective for cerebral dysfunctions, which are due to reductions in the brain neuron levels of brain aromatic monamines, such as depression, bulimia, autism, impaired consciousness and concentration, cognitive disorders and other central mental disorders, as well as myotonia, rigidity, tremors, and other central motor disorders.
Inventors:
HASEGAWA, Hiroyuki (8-24 Kudan-minami 4-chome, Chiyoda-k, Tokyo 75, 〒1028275, JP)
長谷川 宏幸 (〒75 東京都千代田区九段南四丁目８番２４号学校法人日本大学内 Tokyo, 〒1028275, JP)
長谷川 宏幸 (〒75 東京都千代田区九段南四丁目８番２４号学校法人日本大学内 Tokyo, 〒1028275, JP)
Application Number:
JP2011/002393
Publication Date:
October 27, 2011
Filing Date:
April 22, 2011
Export Citation:
Assignee:
NIHON UNIVERSITY (8-24, Kudan-minami 4-chome Chiyoda-k, Tokyo 75, 〒1028275, JP)
学校法人日本大学 (〒75 東京都千代田区九段南四丁目８番２４号 Tokyo, 〒1028275, JP)
HASEGAWA, Hiroyuki (8-24 Kudan-minami 4-chome, Chiyoda-k, Tokyo 75, 〒1028275, JP)
学校法人日本大学 (〒75 東京都千代田区九段南四丁目８番２４号 Tokyo, 〒1028275, JP)
HASEGAWA, Hiroyuki (8-24 Kudan-minami 4-chome, Chiyoda-k, Tokyo 75, 〒1028275, JP)
International Classes:
C07D475/04; A23L1/30; A23L2/52; A61K31/519; A61P25/14; A61P25/16; A61P25/24; A61P25/28
Attorney, Agent or Firm:
NIWA, Shunsuke (3F SHIMOKITAZAWA-SHINKO BUILDING, 37-3 Kitazawa 2-chome, Setagaya-k, Tokyo 31, 〒1550031, JP)
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Claims: