Title:
MEDICINAL COMPOSITION FOR IMPROVING PROGNOSIS AFTER RESTART OF PATIENT'S OWN HEARTBEAT
Document Type and Number:
WIPO Patent Application WO/2017/115705
Kind Code:
A1
Abstract:
[Problem] To provide a medicinal composition that is capable of improving the prognosis after the restart of the patient's own heartbeat even after the passage of a considerably long period of time after the restart of the patient's own heartbeat.
[Solution] A gaseous medicinal composition for improving the prognosis after the restart of the patient's own heartbeat, said medicinal composition being to be administered to a human subject after the passage of at least 30 minutes after the restart of the patient's own heartbeat following cardiorespiratory arrest for at least 10 minutes. The medicinal composition according to the present invention, which contains hydrogen gas, is characterized in that a group of human patients administered with the medicinal composition shows improved prognosis after the restart of the patient's own heartbeat compared with another group of human patients not administered with the medicinal composition.
Inventors:
SUZUKI MASARU (JP)
HAYASHIDA KEI (JP)
TAMURA TOMOYOSHI (JP)
SANO MOTOAKI (JP)
NISHIWAKI YOSHIKI (JP)
HAYASHIDA KEI (JP)
TAMURA TOMOYOSHI (JP)
SANO MOTOAKI (JP)
NISHIWAKI YOSHIKI (JP)
Application Number:
PCT/JP2016/088172
Publication Date:
July 06, 2017
Filing Date:
December 21, 2016
Export Citation:
Assignee:
UNIV KEIO (JP)
TAIYO NIPPON SANSO CORP (JP)
TAIYO NIPPON SANSO CORP (JP)
International Classes:
A61P9/10; A61K33/00; A61P25/28; A61P39/06
Domestic Patent References:
| WO2007021034A1 | 2007-02-22 |
Foreign References:
| JP2011184398A | 2011-09-22 |
Other References:
NORIKO KANEDA ET AL.: "Rat Kan Kyoketsu Saikanryu Shogai Model ni Okeru Konodo Suiso Gas no Postconditioning Koka", BULLETIN OF JAPAN RESEARCH ASSOCIATION FOR THE MEDICAL & HYGIENIC USE OF OZONE, vol. 21, no. 3, 2014, pages 88 - 94, XP009511787, ISSN: 2186-3784
OHSAWA, I. ET AL.: "Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals", NATURE MEDICINE, vol. 13, no. 6, 2007, pages 688 - 694, XP002700155, ISSN: 1078-8956
HAYASHIDA, K. ET AL.: "H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model", JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol. 1, no. 5, 12 October 2012 (2012-10-12), pages 1 - 13, XP055512240
HAYASHIDA, K. ET AL.: "Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management", CIRCULATION, vol. 130, 16 December 2014 (2014-12-16), pages 2173 - 2180, XP055512247, ISSN: 0009-7322
MOTOAKI SANO: "The Potential of Hydrogen Gas as a Novel Medical Gas", MEDICAL GASES, vol. 15, no. 1, 2013, pages 45 - 48, XP009512421, ISSN: 2434-6152
NAT MED., vol. 13, no. 6, June 2007 (2007-06-01), pages 688 - 94
JOURNAL OF APPLIED PHYSIOLOGY, vol. 76, no. 3, 1 March 1994 (1994-03-01), pages 1113 - 1118
HAYASHIDA K; SANO M; HORI S ET AL., JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2012
CIRCULATION, vol. 130, no. 24, 9 December 2014 (2014-12-09), pages 2173 - 80
CIRCULATION, vol. 105, 2002, pages 2332 - 2336
PROC. NATL. ACAD. SCI. USA, vol. 86, June 1989 (1989-06-01), pages 4695 - 4699
OHSAWA, I. ET AL.: "Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals", NATURE MEDICINE, vol. 13, no. 6, 2007, pages 688 - 694, XP002700155, ISSN: 1078-8956
HAYASHIDA, K. ET AL.: "H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model", JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol. 1, no. 5, 12 October 2012 (2012-10-12), pages 1 - 13, XP055512240
HAYASHIDA, K. ET AL.: "Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management", CIRCULATION, vol. 130, 16 December 2014 (2014-12-16), pages 2173 - 2180, XP055512247, ISSN: 0009-7322
MOTOAKI SANO: "The Potential of Hydrogen Gas as a Novel Medical Gas", MEDICAL GASES, vol. 15, no. 1, 2013, pages 45 - 48, XP009512421, ISSN: 2434-6152
NAT MED., vol. 13, no. 6, June 2007 (2007-06-01), pages 688 - 94
JOURNAL OF APPLIED PHYSIOLOGY, vol. 76, no. 3, 1 March 1994 (1994-03-01), pages 1113 - 1118
HAYASHIDA K; SANO M; HORI S ET AL., JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2012
CIRCULATION, vol. 130, no. 24, 9 December 2014 (2014-12-09), pages 2173 - 80
CIRCULATION, vol. 105, 2002, pages 2332 - 2336
PROC. NATL. ACAD. SCI. USA, vol. 86, June 1989 (1989-06-01), pages 4695 - 4699
Attorney, Agent or Firm:
NANJO, Masahiro et al. (JP)
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