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Document Type and Number:
WIPO Patent Application WO/2019/188950
Kind Code:
A medicinal composition for treating a central neurodegenerative disease, said medicinal composition comprising at least one member selected from the group consisting of nicotine, nobiletin, sinensetin and Nchinpi, characterized in that the central neurodegenerative disease is associated with mitochondrial dysfunction.

YAMAKUNI Toru (2-1-1 Katahira, Aoba-ku, Sendai-sh, Miyagi 77, 〒9808577, JP)
KAWAHATA Ichiro (2-1-1 Katahira, Aoba-ku, Sendai-sh, Miyagi 77, 〒9808577, JP)
Application Number:
Publication Date:
October 03, 2019
Filing Date:
March 25, 2019
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TOHOKU UNIVERSITY (2-1-1, Katahira Aoba-ku, Sendai-sh, Miyagi 77, 〒9808577, JP)
International Classes:
A61K31/465; A61K31/352; A61K36/752; A61P25/00; A61P37/02; A61P43/00; G01N33/15; G01N33/50
Domestic Patent References:
Other References:
SAXENA, G. ET AL.: "ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor", BEHAVIOURAL BRAIN RESEARCH, vol. 224, no. 1, 2011, pages 50 - 57, XP028346704, ISSN: 0166-4328, doi:10.1016/j.bbr.2011.04.039
YOUN, K. ET AL.: "Polymethoxyflavones: Novel beta- secretase (BACE1) inhibitors from citrus peels", NUTRIENTS, vol. 9, no. 9, 2017, pages 1 - 12, XP055638572, ISSN: 2072-6643
CHTOUROU, Y. ET AL.: "Naringenin mitigates iron-induced anxiety-like behavioral impairment, mitochondrial dysfunctions, ectonucleotidases and acetylcholinesterase alteration activities in rat hippocampus", NEUROCHEMICAL RESEARCH, vol. 40, no. 8, 2015, pages 1563 - 1575, XP055638574, ISSN: 0364-3190
TAOKA, MASATO ET AL.: "V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 8, 2003, pages 5864 - 5870, XP055638575, ISSN: 0021-9258
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (Kojimachi Business Center, 5-3-1 Kojimachi, Chiyoda-k, Tokyo 83, 〒1020083, JP)
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