Title:
MEDICINAL COMPOSITIONS FOR PREVENTING OR TREATING DIARRHEA
Document Type and Number:
WIPO Patent Application WO/2001/000217
Kind Code:
A1
Abstract:
Medicinal compositions for preventing or treating diarrhea which contain, as the active ingredient, siastain B or its derivatives having a $g(b)-glucuronidase inhibitory activity and are useful as preventives or remedies for diarrhea whereby diarrhea disorders occurring in patients with cancer as the side effect of the administration of chemotherapeutics for cancer (in particular, anticancer camptothecin derivatives serving as a topo isomerase I inhibitor) can be ameliorated. These compositions are efficacious in preventing and treating diarrhea associating the administration of anticancer camptothecin derivatives.
Inventors:
TAKEUCHI TOMIO (JP)
MURAOKA YASUHIKO (JP)
NISHIMURA YOSHIO (JP)
TERAYAMA YOSHIHIKO (JP)
OKADA MINEAKI (JP)
AKIYAMA YUJI (JP)
EKIMOTO HISAO (JP)
MURAOKA YASUHIKO (JP)
NISHIMURA YOSHIO (JP)
TERAYAMA YOSHIHIKO (JP)
OKADA MINEAKI (JP)
AKIYAMA YUJI (JP)
EKIMOTO HISAO (JP)
Application Number:
PCT/JP2000/004264
Publication Date:
January 04, 2001
Filing Date:
June 28, 2000
Export Citation:
Assignee:
ZAIDAN HOJIN BISEIBUTSU (JP)
MEIJI SEIKA KAISHA (JP)
NIPPON KAYAKU KK (JP)
TAKEUCHI TOMIO (JP)
MURAOKA YASUHIKO (JP)
NISHIMURA YOSHIO (JP)
TERAYAMA YOSHIHIKO (JP)
OKADA MINEAKI (JP)
AKIYAMA YUJI (JP)
EKIMOTO HISAO (JP)
MEIJI SEIKA KAISHA (JP)
NIPPON KAYAKU KK (JP)
TAKEUCHI TOMIO (JP)
MURAOKA YASUHIKO (JP)
NISHIMURA YOSHIO (JP)
TERAYAMA YOSHIHIKO (JP)
OKADA MINEAKI (JP)
AKIYAMA YUJI (JP)
EKIMOTO HISAO (JP)
International Classes:
A61K31/445; A61K31/47; A61K31/7012; A61K45/06; A61P1/12; C07H7/02; C07H13/04; C07H13/12; (IPC1-7): A61K31/7012; A61P1/12
Other References:
TAKAHIKO SATOH ET AL.: "Synthesis and antimetastatic activity of 6-trichloroacetamido and 6-guanidino analogues of siastatin B", THE JOURNAL OF ANTIBIOTICS, vol. 49, no. 3, March 1996 (1996-03-01), pages 321 - 325, XP002931720
YOSHIO NISHIMURA ET AL.: "Totally synthetic analogues of siastatin B III. Trifluoroacetamide analogues having inhibitory activity for tumor metastasis", THE JOURNAL OF ANTIBIOTICS, vol. 47, no. 1, January 1994 (1994-01-01), pages 101 - 107, XP002931721
KIYOSHI TAKASUNA ET AL.: "Protective effects of Kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats", JPN. J. CANCER RES., vol. 86, October 1995 (1995-10-01), pages 978 - 984, XP002931722
KIYOSHI TAKASUNA ET AL.: "Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats", CANCER RES., vol. 56, August 1996 (1996-08-01), pages 3752 - 3757, XP002931723
YOSHIO NISHIMURA ET AL.: "Totally synthetic analogues of siastatin B III. Trifluoroacetamide analogues having inhibitory activity for tumor metastasis", THE JOURNAL OF ANTIBIOTICS, vol. 47, no. 1, January 1994 (1994-01-01), pages 101 - 107, XP002931721
KIYOSHI TAKASUNA ET AL.: "Protective effects of Kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats", JPN. J. CANCER RES., vol. 86, October 1995 (1995-10-01), pages 978 - 984, XP002931722
KIYOSHI TAKASUNA ET AL.: "Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats", CANCER RES., vol. 56, August 1996 (1996-08-01), pages 3752 - 3757, XP002931723
Attorney, Agent or Firm:
Yagita, Shigeru (Nishi Shimbashi 1-chome Minato-ku Tokyo, JP)
Download PDF: