Title:
MEDICINAL COMPOUNDS AS ANTAGONISTS OF THE PLATELET- ACTIVATING FACTOR RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2006/116905
Kind Code:
A1
Abstract:
The invention discloses medicinal compounds as antagonists of the platelet-activating factor receptor with a nitrogen-containing group linked to the 10-hydroxyl of ginkgolide B. The invention compounds have improved water-solubility, bioavailability and therapeutic effect. Especially, the water-solubility, bioavailability and therapeutic effect of the salts of the compounds have been improved remarkably.
Inventors:
QIN YINLIN (CN)
XIA PENG (CN)
ZHANG QIAN (CN)
CHEN YING (CN)
HE LONGQI (CN)
XIA PENG (CN)
ZHANG QIAN (CN)
CHEN YING (CN)
HE LONGQI (CN)
Application Number:
PCT/CN2005/002390
Publication Date:
November 09, 2006
Filing Date:
December 30, 2005
Export Citation:
Assignee:
QIN YINLIN (CN)
XIA PENG (CN)
ZHANG QIAN (CN)
CHEN YING (CN)
HE LONGQI (CN)
XIA PENG (CN)
ZHANG QIAN (CN)
CHEN YING (CN)
HE LONGQI (CN)
International Classes:
C07D493/22; A61P7/02; C07D307/00
Foreign References:
| CN1139435A | 1997-01-01 | |||
| CN1472214A | 2004-02-04 | |||
| US6693091B2 | 2004-02-17 |
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD. (Nanjing, Jiangsu 8, CN)
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