Title:
MEDICINE CONTAINING ETS1 INHIBITOR AS ACTIVE INGREDIENT AND METHOD FOR SCREENING SAME
Document Type and Number:
WIPO Patent Application WO/2024/029625
Kind Code:
A1
Abstract:
This medicine contains, as an active ingredient, an ETS1 inhibitor that inhibits the expression or function of ETS Proto-Oncogene 1, Transcription Factor (ETS1) in a fibroblast-specific manner.
Inventors:
TAKAYANAGI HIROSHI (JP)
OKUDA KOMATSU NORIKO (JP)
TSUKASAKI MASAYUKI (JP)
YAN MINGLU (JP)
OKUDA KOMATSU NORIKO (JP)
TSUKASAKI MASAYUKI (JP)
YAN MINGLU (JP)
Application Number:
PCT/JP2023/028599
Publication Date:
February 08, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K45/00; A61P1/00; A61P19/02; A61P35/00; G01N33/15
Other References:
VAN BEEK JONATHANP, KENNEDY LAURA, ROCKEL JASONS, BERNIER SUZANNEM, LEASK ANDREW: "The induction of CCN2 by TGFβ1 involves Ets-1 J", ARTHRITIS RESEARCH AND THERAPY, BIOMED CENTRAL, LONDON, GB, vol. 8, no. 2, 1 January 2006 (2006-01-01), GB , pages R36, XP093136137, ISSN: 1478-6354, DOI: 10.1186/ar1890
XIAO FU-HUI, YU QIN, DENG ZHI-LI, YANG KE, YE YUNSHUANG, GE MING-XIA, YAN DONGJING, WANG HAO-TIAN, CHEN XIAO-QIONG, YANG LI-QIN, Y: "ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity", SCIENCE ADVANCES, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 8, no. 17, 29 April 2022 (2022-04-29), US , pages eabf2017, XP093136136, ISSN: 2375-2548, DOI: 10.1126/sciadv.abf2017
YAN MINGLU, KOMATSU NORIKO, MURO RYUNOSUKE, HUYNH NAM CONG-NHAT, TOMOFUJI YOSHIHIKO, OKADA YUKINORI, SUZUKI HIROSHI I., TAKABA HIR: "ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts", NATURE IMMULOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 23, no. 9, 1 September 2022 (2022-09-01), New York , pages 1330 - 1341, XP093136138, ISSN: 1529-2908, DOI: 10.1038/s41590-022-01285-0
YAN MINGLU, KOMATSU NORIKO, MURO RYUNOSUKE, TAKABA HIROYUKI, NITTA TAKESHI, OKAMOTO KAZUO, TSUKASAKI MASAYUKI, TAKAYANAGI HIROSHI: "Abstract Number: 0051. Identification of a Transcription Factor That Drives Polarization Toward Tissue-destructive Fibroblasts in Arthritis", ARTHRITIS & RHEUMATOLOGY, JOHN WILEY & SONS, INC., US, vol. 74, no. S9, 1 November 2022 (2022-11-01), US , pages 79 - 81, XP093136141, ISSN: 2326-5191, DOI: 10.1002/art.42355
XIAO FU-HUI, YU QIN, DENG ZHI-LI, YANG KE, YE YUNSHUANG, GE MING-XIA, YAN DONGJING, WANG HAO-TIAN, CHEN XIAO-QIONG, YANG LI-QIN, Y: "ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity", SCIENCE ADVANCES, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 8, no. 17, 29 April 2022 (2022-04-29), US , pages eabf2017, XP093136136, ISSN: 2375-2548, DOI: 10.1126/sciadv.abf2017
YAN MINGLU, KOMATSU NORIKO, MURO RYUNOSUKE, HUYNH NAM CONG-NHAT, TOMOFUJI YOSHIHIKO, OKADA YUKINORI, SUZUKI HIROSHI I., TAKABA HIR: "ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts", NATURE IMMULOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 23, no. 9, 1 September 2022 (2022-09-01), New York , pages 1330 - 1341, XP093136138, ISSN: 1529-2908, DOI: 10.1038/s41590-022-01285-0
YAN MINGLU, KOMATSU NORIKO, MURO RYUNOSUKE, TAKABA HIROYUKI, NITTA TAKESHI, OKAMOTO KAZUO, TSUKASAKI MASAYUKI, TAKAYANAGI HIROSHI: "Abstract Number: 0051. Identification of a Transcription Factor That Drives Polarization Toward Tissue-destructive Fibroblasts in Arthritis", ARTHRITIS & RHEUMATOLOGY, JOHN WILEY & SONS, INC., US, vol. 74, no. S9, 1 November 2022 (2022-11-01), US , pages 79 - 81, XP093136141, ISSN: 2326-5191, DOI: 10.1002/art.42355
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
Download PDF: