Title:
MEDICINE FOR REDUCING ADVERSE EFFECTS OF PIRFENIDONE
Document Type and Number:
WIPO Patent Application WO/2021/107060
Kind Code:
A1
Abstract:
Because of the ability to improve symptoms of pellagra, this medicine can reduce adverse effects of pirfenidone administration such as photosensitivity and nausea, and therefore is useful as an agent for reducing adverse effects of pirfenidone.
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Inventors:
YOSHIOKA TAKESHI (JP)
KUROITA TOMOHIRO (JP)
KUROITA TOMOHIRO (JP)
Application Number:
PCT/JP2020/044123
Publication Date:
June 03, 2021
Filing Date:
November 26, 2020
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
A61K45/00; A61K31/4418; A61K31/455; A61K47/22; A61P3/02; A61P11/00; A61P43/00
Foreign References:
| JP2009518293A | 2009-05-07 |
Other References:
GLASSBERG, M. K. ET AL.: "Cardiovascular risks, bleeding risks, and clinical events from 3 phase iii trials of pirfenidone in patients with idiopathic pulmonary fibrosis", ADVANCES IN THERAPY, vol. 36, 10 August 2019 (2019-08-10), pages 2910 - 2926, XP036899073, ISSN: 0741-238X, DOI: 10.1007/s12325-019-01052-y
NEKOMOTO, CHINA MI ET AL.: "Effects of antioxidants on Pirfenidone-induced phototoxicity", THE 46TH ANNUAL MEETING OF THE JAPANESE SOCIETY OF TOXICOLOGY, POSTER SESSION, 10 July 2019 (2019-07-10)
TANAKA, YOSHIAKI ET AL.: "Oxidative stress and antioxidant", JOURNAL OF JAPANESE SOCIETY FOR PARENTERAL AND ENTERAL NUTRITION, vol. 31, no. 1, 2016, pages 3 - 12, XP055832780, ISSN: 2189- 017X
STONE, T. W. ET AL.: "Endogenous kynurenines as targets tor drug discovery and development", NATURE REVIEWS DRUG DISCOVERY, vol. 1, 2002, pages 609 - 620, XP008034547, ISSN: 1474-1784, DOI: 10.1038/nrd870
NEKOMOTO, CHINA MI ET AL.: "Effects of antioxidants on Pirfenidone-induced phototoxicity", THE 46TH ANNUAL MEETING OF THE JAPANESE SOCIETY OF TOXICOLOGY, POSTER SESSION, 10 July 2019 (2019-07-10)
TANAKA, YOSHIAKI ET AL.: "Oxidative stress and antioxidant", JOURNAL OF JAPANESE SOCIETY FOR PARENTERAL AND ENTERAL NUTRITION, vol. 31, no. 1, 2016, pages 3 - 12, XP055832780, ISSN: 2189- 017X
STONE, T. W. ET AL.: "Endogenous kynurenines as targets tor drug discovery and development", NATURE REVIEWS DRUG DISCOVERY, vol. 1, 2002, pages 609 - 620, XP008034547, ISSN: 1474-1784, DOI: 10.1038/nrd870
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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