Title:
MEDIUM, FOR CULTURING CORNEAL ENDOTHELIAL CELLS, CONTAINING CONDITIONED MEDIUM FROM MESENCHYMAL STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2014/038639
Kind Code:
A1
Abstract:
[Problem] To provide, in order to manufacture cells to transplant into patients with corneal endothelial failure, a medium used to culture corneal endothelial cells obtained from human corneal tissue and grow said cells while maintaining the morphology thereof as corneal endothelial cells. [Solution] A medium containing a conditioned medium from mesenchymal stem cells; and a method in which said medium is used to culture corneal endothelial cells.
More Like This:
Inventors:
HAGIYA MICHIO (JP)
IMAGAWA KIWAMU (JP)
HOSODA YUUKI (JP)
KOIZUMI NORIKO (JP)
OKUMURA NAOKI (JP)
NAKAHARA MAKIKO (JP)
KINOSHITA SHIGERU (JP)
IMAGAWA KIWAMU (JP)
HOSODA YUUKI (JP)
KOIZUMI NORIKO (JP)
OKUMURA NAOKI (JP)
NAKAHARA MAKIKO (JP)
KINOSHITA SHIGERU (JP)
Application Number:
PCT/JP2013/073989
Publication Date:
March 13, 2014
Filing Date:
September 05, 2013
Export Citation:
Assignee:
JAPAN CHEM RES (JP)
DOSHISHA (JP)
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
DOSHISHA (JP)
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
International Classes:
C12N1/00; A61K35/44; A61P27/02; C12N5/0775
Domestic Patent References:
| WO2013100208A1 | 2013-07-04 | |||
| WO2009028631A1 | 2009-03-05 |
Foreign References:
| JP2010500047A | 2010-01-07 | |||
| JP2004024852A | 2004-01-29 | |||
| JP2006187281A | 2006-07-20 | |||
| JP2005229869A | 2005-09-02 | |||
| JP2006204527A | 2006-08-10 | |||
| JPH07500001A | 1995-01-05 |
Other References:
LU, X. ET AL.: "Enhanced survival in vitro of human corneal endothelial cells using mouse embryonic stem cell conditioned medium", MOLECULAR VISION, vol. 16, 2010, pages 611 - 622, XP055192468
LEE, M.J. ET AL.: "Enhancement of wound healing by secretory factors of endothelial precursor cells derived from human embryonic stem cells", CYTOTHERAPY, vol. 13, 2011, pages 165 - 178, XP055192470
WALTER, M.N.M. ET AL.: "Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays", EXPERIMENTAL CELL RESEARCH, vol. 316, 2010, pages 1271 - 1281, XP055192472
WANG, C.-Y. ET AL.: "Mesenchymal Stem Cell- Conditioned Medium Facilitates Angiogenesis and Fracture Healing in Diabetic Rats", MOL. THER., vol. 19, no. 7, 2011, pages 1394, XP055192479
PEH, G.S.L. ET AL.: "Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview", TRANSPLANTATION, vol. 91, no. 8, 2011, pages 811 - 819, XP055192483
JOYCE, N.C. ET AL.: "Human Corneal Endothelial Cell Proliferation Potential for Use in Regenerative Medicine", CORNEA, MATERIALS AND METHODS, vol. 23, no. L, 2004, pages S8 - S19, XP008104597
NORIKO KOIZUMI: "Development of new therapeutic modalities for corneal endothelial disease using somatic stem cells", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 241, no. 10, 9 June 2012 (2012-06-09), pages 765 - 770, XP008176663
KOIZUMI, N. ET AL.: "Progress in the Development of Corneal Endothelial Tissue Engineering for Future Clinical Application", THE SCIENCE AND ENGINEERING REVIEW OF DOSHISHA UNIVERSITY, vol. 52, no. 4, 2012, pages 31 - 36, XP008176507
NAKAHARA, M. ET AL.: "Corneal Endothelial Expansion Promoted by Human Bone Marrow Mesenchymal Stem Cell-Derived Conditioned Medium", PLOS ONE, vol. 8, no. 7, 23 June 2013 (2013-06-23), pages E69009, XP055192494
PRICE FW. JR. ET AL., J REFRACT SURG., vol. 21, 2005, pages 339 - 45
PEH GSL. ET AL., TRANSPLANTATION, vol. 91, 2011, pages 811 - 9
KOIZUMI N., THE SCIENCE ENGINEERING REVIEW OF DOSHISHA UNIV., vol. 52, 2012, pages 31 - 36
MIYATA K. ET AL., CORNEA, vol. 20, 2001, pages 59 - 63
WATANABE K. ET AL., NAT BIOTECHNOL., vol. 25, 2007, pages 681
JOYCE NC. ET AL., CORNEA, vol. 23, 2004, pages 8 - 19
LEE, M.J. ET AL.: "Enhancement of wound healing by secretory factors of endothelial precursor cells derived from human embryonic stem cells", CYTOTHERAPY, vol. 13, 2011, pages 165 - 178, XP055192470
WALTER, M.N.M. ET AL.: "Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays", EXPERIMENTAL CELL RESEARCH, vol. 316, 2010, pages 1271 - 1281, XP055192472
WANG, C.-Y. ET AL.: "Mesenchymal Stem Cell- Conditioned Medium Facilitates Angiogenesis and Fracture Healing in Diabetic Rats", MOL. THER., vol. 19, no. 7, 2011, pages 1394, XP055192479
PEH, G.S.L. ET AL.: "Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview", TRANSPLANTATION, vol. 91, no. 8, 2011, pages 811 - 819, XP055192483
JOYCE, N.C. ET AL.: "Human Corneal Endothelial Cell Proliferation Potential for Use in Regenerative Medicine", CORNEA, MATERIALS AND METHODS, vol. 23, no. L, 2004, pages S8 - S19, XP008104597
NORIKO KOIZUMI: "Development of new therapeutic modalities for corneal endothelial disease using somatic stem cells", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 241, no. 10, 9 June 2012 (2012-06-09), pages 765 - 770, XP008176663
KOIZUMI, N. ET AL.: "Progress in the Development of Corneal Endothelial Tissue Engineering for Future Clinical Application", THE SCIENCE AND ENGINEERING REVIEW OF DOSHISHA UNIVERSITY, vol. 52, no. 4, 2012, pages 31 - 36, XP008176507
NAKAHARA, M. ET AL.: "Corneal Endothelial Expansion Promoted by Human Bone Marrow Mesenchymal Stem Cell-Derived Conditioned Medium", PLOS ONE, vol. 8, no. 7, 23 June 2013 (2013-06-23), pages E69009, XP055192494
PRICE FW. JR. ET AL., J REFRACT SURG., vol. 21, 2005, pages 339 - 45
PEH GSL. ET AL., TRANSPLANTATION, vol. 91, 2011, pages 811 - 9
KOIZUMI N., THE SCIENCE ENGINEERING REVIEW OF DOSHISHA UNIV., vol. 52, 2012, pages 31 - 36
MIYATA K. ET AL., CORNEA, vol. 20, 2001, pages 59 - 63
WATANABE K. ET AL., NAT BIOTECHNOL., vol. 25, 2007, pages 681
JOYCE NC. ET AL., CORNEA, vol. 23, 2004, pages 8 - 19
Attorney, Agent or Firm:
SHA Takuho (JP)
謝 卓峰 (JP)
謝 卓峰 (JP)
Download PDF:
Previous Patent: ULTRASONIC ENDOSCOPE
Next Patent: DEVICE FOR IDENTIFYING AND DISPENSING SAMPLES AND METHOD FOR IDENTIFYING AND DISPENSING SAMPLES
Next Patent: DEVICE FOR IDENTIFYING AND DISPENSING SAMPLES AND METHOD FOR IDENTIFYING AND DISPENSING SAMPLES